Enrique Ortega-Forte
Exchange PhD Student
Chimie ParisTech
PSL University
CNRS
Institute of Chemistry for Life and Health Sciences
Laboratory for Inorganic Chemical Biology
+33 1 85 78 41 53
enrique.ortega-forte@chimieparistech.psl.eu
Enrique was born in Murcia (Spain) in 1994. He obtained his BSc in Biochemistry and Biomedical Sciences from the University of Valencia and University of Leeds (UK) and a MSc in Pharmacology from the University of Granada. At present, he is conducting PhD studies at the University of Murcia under supervision of Prof. José Ruiz, focused on the development of novel photoactive metallodrugs with anticancer activity, and is currently joining the Gasser Group at Chimie ParisTech to complete his thesis work.
Outside of the lab, Enrique enjoys trekking, sports, martial arts and music festivals.
Publications
[1] Bonelli, J.; Ortega-Forte, E.; Rovira, A.; Bosch, M.; Torres, O.; Cuscó, C.; Rocas, J.; Ruiz, J.; Marchán, V. Improving Photodynamic Therapy Anticancer Activity of a Mitochondria-Targeted Coumarin Photosensitizer Using a Polyurethane–Polyurea Hybrid Nanocarrier. Biomacromolecules 2022, 23 [7], 2900–2913. https://doi.org/10.1021/acs.biomac.2c00361
[2] Ortega-Forte, E.; Vigueras, G.; Ballester, F. J.; Ruiz, J. Targeting Translation: A Promising Strategy for Anticancer Metallodrugs. Coordination Chemistry Reviews 2021, 446, 214129. https://doi.org/10.1016/j.ccr.2021.214129
[3] Ortega-Forte, E.; Rovira, A.; Gandioso, A.; Bonelli, J.; Bosch, M.; Ruiz, J.; Marchán, V. COUPY Coumarins as Novel Mitochondria-Targeted Photodynamic Therapy Anticancer Agents. J. Med. Chem. 2021. https://doi.org/10.1021/acs.jmedchem.1c01254
[4] Ortega-Forte, E.; Pérez-Arnaiz, C.; Rodríguez, V.; Janiak, C.; Busto, N.; García, B.; Ruiz, J. A 2-(Benzothiazol-2-Yl)-Phenolato Platinum(II) Complex as Potential Photosensitizer for Combating Bacterial Infections in Lung Cancer Chemotherapy†. European Journal of Medicinal Chemistry 2021, 222, 113600. https://doi.org/10.1016/j.ejmech.2021.113600
[5] Zamora, A.; Wachter, E.; Vera, M.; Heidary, D. K.; Rodríguez, V.; Ortega, E.; Fernández-Espín, V.; Janiak, C.; Glazer, E. C.; Barone, G.; Ruiz, J. Organoplatinum(II) Complexes Self-Assemble and Recognize AT-Rich Duplex DNA Sequences. Inorg. Chem. 2021, 60, 2178–3287. https://doi.org/10.1021/acs.inorgchem.0c02648
[6] Martínez-Carmona, M.; Ho, Q. P.; Morand, J.; García, A.; Ortega, E.; Erthal, L. C. S.; Ruiz-Hernandez, E.; Santana, M. D.; Ruiz, J.; Vallet-Regí, M.; Gun’ko, Y. K. Amino-Functionalized Mesoporous Silica Nanoparticle-Encapsulated Octahedral Organoruthenium Complex as an Efficient Platform for Combatting Cancer. Inorg. Chem. 2020, 59 [14], 10275–10284. https://doi.org/10.1021/acs.inorgchem.0c01436
[7] Ballester, F. J.; Ortega, E.; Bautista, D.; Santana, M. D.; Ruiz, J. Ru[II] Photosensitizers Competent for Hypoxic Cancers via Green Light Activation. Chem. Commun. 2020, 56 [71], 10301–10304. https://doi.org/10.1039/D0CC02417A
[8] Ortega-Forte, E.; Ballester, F.-J.; Hernández-García, A.; Hernandez-Garcia, S.; Guerrero-Rubio, M. A.; Bautista, D.; Santana, M. D.; Gandia-Herrero, F.; Ruiz, J. Novel Organo-Osmium(II) Proteosynthesis Inhibitors Active against Human Ovarian Cancer Cells Reduces Gonad Tumor Growth in Caenorhabditis Elegans. Inorg. Chem. Front. 2020. https://doi.org/10.1039/C9QI01704F
[9] Ortega, E.; Zamora, A.; Basu, U.; Lippmann, P.; Rodríguez, V.; Janiak, C.; Ott, I.; Ruiz, J. An Erlotinib Gold(I) Conjugate for Combating Triple-Negative Breast Cancer. Journal of Inorganic Biochemistry 2020, 203, 110910. https://doi.org/10.1016/j.jinorgbio.2019.110910
[10] González, J. J.; Ortega, E.; Rothemund, M.; Gold, M.; Vicente, C.; de Haro, C.; Bautista, D.; Schobert, R.; Ruiz, J. Luminescent Gold(I) Complexes of 1-Pyridyl-3-Anthracenylchalcone Inducing Apoptosis in Colon Carcinoma Cells and Antivascular Effects. Inorg. Chem. 2019, 58 [19], 12954–12963. https://doi.org/10.1021/acs.inorgchem.9b01901
[11] Ballester, F.-J.; Ortega, E.; Porto, V.; Kostrhunova, H.; Davila-Ferreira, N.; Bautista, D.; Brabec, V.; Santana, M. D.; Domínguez, F.; Ruiz, J. New Half-Sandwich Ruthenium(II) Complexes as Proteosynthesis Inhibitors in Cancer Cells. Chem. Commun. 2019, No. 8, 1140–1143. https://doi.org/10.1039/C8CC09211G
[12] Ortega, E.; Yellol, J. G.; Rothemund, M.; Ballester, F. J.; Rodríguez, V.; Yellol, G.; Janiak, C.; Schobert, R.; Ruiz, J. A New C,N-Cyclometalated Osmium(II) Arene Anticancer Scaffold with a Handle for Functionalization and Antioxidative Properties. Chem. Commun. 2018, 54 [79], 11120–11123. https://doi.org/10.1039/C8CC06427J