Journal Articles

2017

  1. A solid phase-assisted approach for the facile synthesis of a highly water-soluble zirconium-89 chelator for radiopharmaceutical development
    M. Briand, M.L. Aulsebrook, T.L. Mindt* and G. Gasser,* Dalton Trans., 2017, accepted, DOI: 10.1039/C7DT03639F.
    DOI: http://dx.doi.org/10.1039/C7DT03639F
  2. Novel Organometallic Oxamniquine Derivatives with Cross-species Activity against Schistosoma mansoni and S. haematobium
    J. Hess, G. Panic, M. Patra, L. Mastrobuoni, O. Blacque, S. Roy, J. Keiser* and G. Gasser,* ACS Infect. Dis., 2017, 3, 645-652.
    DOI: http://dx.doi.org/10.1021/acsinfecdis.7b00054
  3. Extending the Excitation Wavelength of Potential Photosensitizers via Appendage of a Kinetically-Stable Terbium(III) Macrocyclic Complex for Applications in Photodynamic Therapy
    P. Ung,* M. Clerc, H. Huang, H. Chao, M. Seitz, B. Boyd, B. Graham and G. Gasser,* Inorg. Chem., 2017, 56, 7960-7974.
    DOI: http://dx.doi.org/10.1021/acs.inorgchem.7b00677
  4. Dinuclear Thiophenolato-Bridged Arene Ruthenium Complexes as Promising Antiparasitic Agents
    A.P. Basto, J. Müller, R. Rubbiani, F. Giannini, G. Süss-Fink, V. Balmer, A. Hemphill,* G. Gasser* and J. Furrer,* Antimicrob. Agents Chemother., 2017, 61, e01031-17.
    DOI: http://dx.doi.org/
  5. Evaluation of the Medicinal Potential of Two Ruthenium(II) Polypyridine Complexes as One- and Two-Photon Photodynamic Therapy Photosensitizers
    J. Hess, H. Huang, A. Kaiser, V. Pierroz, O. Blacque, H. Chao,* G. Gasser,* Chem. Eur. J., 2017, 23, 9888-9896.
    DOI: http://dx.doi.org/10.1002/chem.201701392
    VIP Article
    Highlighted in ChemistryViews
  6. Immobilisation of multiple ligands using peptide nucleic acids: a strategy to prepare the microenvironment for cell culture
    E.-J. Lee, C. Mari, M. Gel, J. Gardiner, G. Gasser and D. Haylock,* ChemistySelect, 2017, 2, 4028-4032.
    DOI: http://dx.doi.org/10.1002/slct.201700541
  7. Combining Imaging and Anticancer Properties with Heterobimetallic Pt(II)/M(I) (M = Re, 99mTc) Complexes
    L. Quental, P. Raposinho, F. Mendes, I. Santos, C. Navarro-Ranninger, A. Alvarez-Valdes, H. Huang, H. Chao, R. Rubbiani, G. Gasser,* A.G. Quiroga* and A. Paulo,* Dalton Trans., 2017, 46, 14523-14536 (invited contribution for the special issue “Frontiers in Radionuclide Imaging and Therapy” dedicated to Prof. Isabel Santos).
    DOI: http://dx.doi.org/10.1039/C7DT00043J
  8. Multi-Stimuli Responsive Block Copolymers as Smart Release Platform for a Polypyridyl Ruthenium Complexes
    M. Appold, C. Mari, C. Lederle, J. Elbert, C. Schmidt, I. Ott, B. Stühn, G. Gasser,* and M. Gallei,* Polym. Chem., 2017, 8, 890-900.
    DOI: http://dx.doi.org/10.1039/c6py02026g OPEN ACCESS
  9. Towards the Synthesis of New Tumor Targeting Photosensitizers for Photodynamic Therapy and Imagining Applications
    G. Mion, C. Mari, T. Da Ros, R. Rubbiani, G. Gasser,* and T. Gianferrara,* ChemistrySelect, 2017, 2, 190-200.
    DOI: http://dx.doi.org/10.1002/slct.201601960
  10. Influence of the Dissolution Solvent on the Cytotoxicity of Octahedral Cationic Ir(III) Hydride Complexes
    H. Huang, N. Humbert, V. Bizet, H. Chao,* C. Mazet,* and G. Gasser,* J. Organomet. Chem., 2017, 839, 15-18 (invited contribution for the special issue on the 8th International Symposium on Bioorganometallic Chemistry).
    DOI: http://dx.doi.org/10.1016/j.jorganchem.2016.12.010
  11. Comparison of the octadentate bifunctional chelator DFO*-pPhe-NCS and the clinically used hexadentate bifunctional chelator DFO-pPhe-NCS for ⁸⁹Zr-immuno-PET
    D.J. Vugts,* C. Klaver, C. Sewing, A.J. Poot, K. Adamzek, S. Huegli, C. Mari. H. G.W.M. Visser, I.E. Valverde, G. Gasser,* T.L. Mindt,* and G.A.M.S. van Dongen, Eur. J. Nucl. Med. Mol. Imag., 2017, 44, 286-295.
    DOI: http://dx.doi.org/10.1007/s00259-016-3499-x OPEN ACCESS
  12. Evaluation of Perylene Bisimide-based RuII and IrIII Complexes as Photosensitizers for Photodynamic Therapy
    C. Mari, H. Huang, R. Rubbiani, M. Schulze, F. Würthner, H. Chao,* and G. Gasser,* Eur. J. Inorg. Chem., 2016, accepted, DOI: 10.1002/ejic.201600516 (invited contribution for the special issue on Metal Anticancer Complexes – Activity, Mechanism of Action and Future perspective).
    DOI: http://dx.doi.org/10.1002/ejic.201600516
  13. Biological Evaluation of Nitrile Containing Ru(II) Polypyridyl Complexes as Potential Photodynamic Therapy Agents
    C. Mari, R. Rubbiani and G. Gasser,* Inorg. Chim. Acta, 2017, 454C, 21-26 (invited article for the special issue in memory of the late Prof. Karen J. Brewer).
    DOI: http://dx.doi.org/10.1016/j.ica.2015.10.010

2016

  1. Assessment of the Nematocidal Activity of Metallocenyl Analogues of Monepantel
    J. Hess, M. Patra, A. Jabbar, V. Pierroz, S. Konatschnig, B. Spingler, S. Ferrari, R.B. Gasser* and G. Gasser* Dalton Trans., 2016, 45, 17662-17671.
    DOI: http://dx.doi.org/10.1039/C6DT03376H OPEN ACCESS
  2. Synthesis, Characterization and Biological Activity of Ferrocenyl Analogues of the Anthelmintic Drug Monepantel
    J. Hess, M. Patra, V. Pierroz, B. Spingler, A. Jabbar, S. Ferrari, R.B. Gasser* and G. Gasser* Organometallics, 2016, 35, 3369–3377.
    DOI: http://dx.doi.org/10.1021/acs.organomet.6b00577
  3. Organometallic Derivatisation of the Nematocidal Drug Monepantel leads to Promising Antiparisitic Drug Candidates
    J. Hess, M. Patra, L. Rangasamy, S. Konatschnig, O. Blacque, A. Jabbar, P. Mac, E.M. Jorgensen, R.B.Gasser,* and G. Gasser, * Chem. Eur. J., 2016, 22, 16602-16612.
    DOI: http://dx.doi.org/10.1002/chem.201602851
  4. N-Heterocyclic Carbene-Polyethyleneimine (PEI) Platinum Complexes show in vitro and in vivo Antitumor Efficacy
    N. Chekkat, G. Dahm, E. Chardon, M. Wantz, J. Sitz, M. Decossas, O. Lambert, B. Frisch, R. Rubbiani, G. Gasser, G. Guichard, S. Fournel,* and S. Bellemin-Laponnaz,* Bioconjugate Chem., 2016, 27, 1942-1948.
    DOI: http://dx.doi.org/10.1021/acs.bioconjchem.6b00320
  5. Dual Mode of Cell Death upon the Photo-Irradiation of a RuII Polypyridyl Complex in Interphase or Mitosis
    V. Pierroz, R. Rubbiani, C. Gentili, M. Patra, C. Mari, G. Gasser,* and S. Ferrari,* Chem. Sci., 2016, 7, 6115-6124.
    DOI: http://dx.doi.org/10.1039/C6SC00387G
  6. Towards 99mTc-based Imaging Agents with Effective Doxorubicin Mimetics: A Molecular and Cellular Study
    S. Imstepf, V. Pierroz, P. Raposinho, M. Felber, T. Fox, C. Fernandes, G. Gasser, I.R. Santos, and R. Alberto,* Dalton Trans., 2016, 45, 13025-13033.
    DOI: http://dx.doi.org/10.1039/C6DT00871B
  7. A Disassembly Strategy for Imaging Endogenous Pyrophosphate in Mitochondria using a FeIII-salen Complex
    N. Kumari, H. Huang, H. Chao, G. Gasser, and F. Zelder, ChemBioChem, 2016, 17, 1211-1215.
    DOI: http://dx.doi.org/10.1002/cbic.201600195
  8. Selective Photorelease of an Organometallic-Containing Enzyme Inhibitor
    A. Leonidova, C. Mari, C. Aebersold, and G. Gasser,* Organometallics, 2016, 5, 851-854.
    DOI: http://dx.doi.org/10.1021/acs.organomet.6b00029
  9. Sedaxicenes: potential new antifungal Ferrocene-based Agents?
    R. Rubbiani,* O. Blacque, and G. Gasser,* Dalton Trans., 2016, 45, 6619-6626.
    DOI: http://dx.doi.org/10.1039/C5DT04231C OPEN ACCESS
  10. Bimodal X-ray and Infrared Imaging of an Organometallic Derivatives of Praziquantel in Schistosoma mansoni
    S. Clède, N. Cowan, F. Lambert, H.C. Bertrand, R. Rubbiani, M. Patra, J. Hess, C. Sandt, N. Trcera, G. Gasser,* J. Keiser,* and C. Policar,* ChemBioChem, 2016, 17, 1004-1007.
    DOI: http://dx.doi.org/10.1002/cbic.201500688
  11. Cellular Uptake and Photo-Cytotoxicity of a Gadolinium(III)-DOTA-Naphtalimide Complex “Clicked” to a lipidated Tat Peptide
    W.I. O’Malley, R. Rubbiani, M.L. Ausebrook, M.R. Grace, L. Spiccia, K.L. Tuck,* G. Gasser,*  and B. Graham,* Molecules, 2016, 21, 194 (invited contribution for the special issue on photoresponsive drugs).
    DOI: http://dx.doi.org/10.3390/molecules21020194 OPEN ACCESS
  12. Luminescent Alkyne-bearing Terbium(III) Complexes and their Application to Bioorthogonal Protein Labeling
    W.I. O’Malley, E.H. Abdelkader, M.L. Ausebrook, R. Rubbiani, C.-T. Loh, M.R. Grace, L. Spiccia, G. Gasser, G. Otting, K.L. Tuck,* and B. Graham,* Inorg. Chem., 2016, 55, 1674-1682.
    DOI: http://dx.doi.org/10.1021/acs.inorgchem.5b02605
  13. Organometallic Rhenium Complexes Divert Doxorubicin to the Mitochondria
    S. Imstepf, V. Pierroz, R. Rubbiani, M. Felber, T. Fox, G. Gasser and R. Alberto,* Angew. Chem. Int. Ed., 2016, 55, 2792-2795.
    DOI: http://dx.doi.org/10.1002/anie.20151143
  14. Synthesis, Characterization and Biological Evaluation of novel Ru(II)-Arene Complexes containing Intercalating Ligands
    S. Nikolic, L. Rangasamy, N. Gligorijevic, S. Arandelovic, S. Radulovic, G. Gasser* and S. Grguric-Sipka,* J. Inorg. Biochem., 2016, 160, 156-165 (invited contribution for the special issue for the COST Action CM1105).
    DOI: http://dx.doi.org/10.1016/j.jinorgbio.2016.01.005
  15. Insertion of Organometallic Moieties into Peptides and Peptide Nucleic Acids using Alternative “Click” Strategies
    C. Mari, S. Mosberger, N. Llorente, S. Spreckelmeyer and G. Gasser,* Inorg. Chem. Frontiers, 2016, 3, 397-405 (invited contribution for the themed issue “Emerging Investigators”).
    DOI: http://dx.doi.org/10.1039/C5QI00270B OPEN ACCESS
  16. A Photocaged Inositol-Pyrophosphate: Synthesis, Cellular Delivery, Photochemical Release, and its Effect on PH-Domain Translocation
    I. Pavlovic, D.T. Thakor, J.R. Vargas, C.J. McKinlay, S. Haucke, P. Anstaett, R.C. Camuna, G. Gasser, C. Schlutz, P.A. Wender,* and H.J. Jessen, Nature Commun., 2016, 7, DOI: 10.1038/ncomms10622.
    DOI: http://dx.doi.org/10.1038/ncomms10622 OPEN ACCESS

2015

  1. Nuclear Targeting with an Auger Electron Emitter Potentiates the Action of a Widely-Used Antineoplastic Drug
    S. Imstepf, V. Pierroz, P. Raposinho, M. Bauwens, M. Felber, T. Fox, A. Shapiro, R. Freudenberg, C. Fernandes, S. Gama, G. Gasser, F. Motthagy, I. Santos, R. Alberto,* Bioconjugate Chem., 2015, 26, 2397-2407.
    DOI: http://dx.doi.org/10.1021/acs.bioconjchem.5b00466
  2. Induction of Cytotoxicity through Photo-release of Aminoferrocene
    A. Leonidova, P. Anstaett, V. Pierroz, C. Mari, B. Spingler, S. Ferrari and G. Gasser,* Inorg. Chem., 2015, 54, 9740-9748.
    DOI: http://dx.doi.org/10.1021/acs.inorgchem.5b01332
  3. Highly Charged Ruthenium(II) Polypyridyl Complexes as Lysosome-Localized Photosensitizers for Two-Photon Photodynamic Therapy
    H. Huang, B. Yu, P. Zhang, J. Huang, Y. Chen, G. Gasser,* L. Ji and H. Chao,* Angew. Chem. Int. Ed., 2015, 54, 14049-14052.
    DOI: http://dx.doi.org/10.1002/anie.201507800
    VIP Article
  4. Two-Photon Uncageable Enzyme Inhibitors bearing Targeting Vectors
    P. Anstaett, V. Pierroz, S. Ferrari, G. Gasser,* Photochem. Photobiol. Sci., 2015, 14, 1821-1825.
    DOI: http://dx.doi.org/10.1039/C5PP00245A OPEN ACCESS
  5. Phototoxic Activity and DNA Interactions of New Water Soluble Porphyrin and their Re(I) Conjugates
    G. Mion, T. Gianferrara,* A. Bergamo, G. Gasser,* V. Pierroz, R. Rubbiani, R. Vilar,* A. Leczkowska and E. Alessio, ChemMedChem, 2015, 10, 1901-1914.
    DOI: http://dx.doi.org/10.1002/cmdc.201500288
  6. In vivo Demonstration of a Tumour Pretargeting Approach with Peptide Nucleic Acids as Complementary System
    A. Leonidova, C. Foerster, K. Zarschler, M. Schubert, H.-J. Pietzsch, J. Steinback, R. Bergmann, N. Metzler-Nolte, H. Stephan, G. Gasser,* Chem. Sci., 2015, 6, 5601-5616. Highlighted on chemie.de, bionity.com, ChemieXtra and Helmholtz Association.
    DOI: http://dx.doi.org/10.1039/C5SC00951K OPEN ACCESS
  7. Unexpected High Photothermal Conversion Efficiency of Gold Nanospheres upon Grafting with Two-Photon Luminescent Ruthenium(II) Complexes: A Way Towards Cancer Therapy?
    P. Zhang, J. Wang, H. Huang, B. Yu, K. Qiu, J. Huang, S. Wang, L. Jiang, G. Gasser, L. Ji and H. Chao,* Biomaterials, 2015, 63, 102-114.
    DOI: http://dx.doi.org/10.1016/j.biomaterials.2015.06.012
  8. Direct Imaging of Biological Sulfur Dioxide Derivatives in Vivo Using a Two-Photon Phosphorescent Probe
    G. Li, Y. Chen, J. Wang, J. Wu, G. Gasser, L. Ji and H. Chao,* Biomaterials, 2015, 63, 128-136.
    DOI: http://dx.doi.org/10.1016/j.biomaterials.2015.06.014
  9. Towards Selective Light-Activated Ru(II)-Based Prodrug Candidates
    C. Mari, V. Pierroz, A. Leonidova, S. Ferrari, and G. Gasser,* Eur. J. Inorg. Chem., 2015, 13, 3879-3891.
    DOI: http://dx.doi.org/10.1002/ejic.201500602
  10. Reply to Commentary by Trentham et al. on “Caged Phosphate and the Slips and Misses in Determination of Quantum Yields for Ultraviolet-A-Induced Photouncaging” by Gasser et al.
    P. Anstaett,* A. Leonidova, E. Janett, C. Bochet* and G. Gasser,* ChemPhysChem, 2015, 16, 1863-1866.
    DOI: http://dx.doi.org/10.1002/cphc.201500178
  11. Caged Phosphate and the Slips and Misses in Determination of Quantum Yields for UV-A Photouncaging
    P. Anstaett, A. Leonidova and G. Gasser* ChemPhysChem, 2015, 16, 1857-1860.
    DOI: http://dx.doi.org/10.1002/cphc.201402547
  12. Internal Labeling Strategy of Large RNAs with Minimal Perturbation Using Fluorescent PNA
    A. Schmitz, S. Zelger-Paulus, G. Gasser,* and R.K.O. Sigel,* ChemBioChem, 2015, 16, 1302-1306.
    DOI: http://dx.doi.org/10.1002/cbic.201500180
  13. (Metallo)porphyrins as Potent Phototoxic Anticancer Agents After Irradiation with Red Light
    P.M. Antoni, A. Naik, I. Albert, R. Rubbiani, S. Gupta, P. Ruiz-Sánchez, P. Munikorn, J. M. Mateos, V. Luginbuehl, P. Thamyongkit, U. Ziegler, G. Gasser, G. Jeschke and B. Spingler,* Chem. Eur. J., 2015, 21, 1179-1183.
    DOI: http://dx.doi.org/10.1002/chem.201405470
  14. An Organometallic Structure-Activity Relationship Study Reveals the Essential Role of a Re(CO)3 Moiety in the Activity Against Gram-Positive Pathogens Including MRSA
    M. Patra, M. Wenzel, P. Prochnow, V. Pierroz, G. Gasser, J.E. Bandow and N. Metzler-Nolte,* Chem. Sci., 2015, 6, 214-224.
    DOI: http://dx.doi.org/10.1039/C4SC02709D OPEN ACCESS

2014

  1. Anticancer Profile of a Series of Gold(III) (2-phenyl)pyridine Complexes
    R. Rubbiani,* T.N. Zehnder, C. Mari, O. Blacque, K. Venkatesan,* and G. Gasser,* ChemMedChem, 2015, 9, 2781-2790.
    DOI: http://dx.doi.org.10.1002/cmdc.201402446
  2. Enantioselective Total Syntheses of the Proposed Structures of Prevezol B and Evaluation of Anti-Cancer Activity
    A.E. Leung, R. Rubbiani, G. Gasser, and K.L. Tuck,* Org. Biomol. Chem., 2014, 12, 8239–8246.
    DOI: http://dx.doi.org/10.1039/C4OB01662A
  3. Synthesis, Characterization and Biological Evaluation of New Ru(II) Polypyridyl Photosensitizers for Photodynamic Therapy
    A. Frei, R. Rubbiani, S. Tubafard, O. Blacque, P. Anstaett, A. Felgentraeger, T. Maisch, L. Spiccia and G. Gasser,* J. Med. Chem., 2014, 57, 7280-7292.
    DOI: http://dx.doi.org.10.1021/jm500566f
    Highly cited article in J. Med. Chem. of the year 2014.
  4. In vitro and in vivo Antischistosomal Activity of Ferroquine Derivative
    J. Keiser,* M. Vargas, R. Rubbiani, G. Gasser, and C. Biot, Parasites & Vectors, 2014, 7, 424.
    DOI: http://dx.doi.org.10.1186/1756-3305-7-424 OPEN ACCESS
  5. An Octadentate Bifunctional Chelating Agent for the Development of Stable Zirconium-89 Based Molecular Imaging Probes
    M. Patra, A. Baumann, C. Mari, C.A. Fischer, O. Blacque, D. Häussinger, G. Gasser* and T.L. Mindt,* Chem. Commun., 2014, 50, 11523-11525.
    DOI: http://dx.doi.org/10.1039/C4CC05558F
  6. Activity of Praziquantel Enantiomers and Main Metabolites against Schistosoma mansoni
    I. Meister, K. Ingram-Sieber, N. Cowan, M.H. Todd, M.N. Robertson, C. Meli, M. Patra, G. Gasser and J. Keiser* Antimicrob. Agents Chemother., 2014, 58, 5466-5472.
    DOI: http://dx.doi.org/10.1128/AAC.02741-14
  7. DNA Intercalating Ru(II) Polypyridyl Complexes as effective Photosensitizers in Photodynamic Therapy
    C. Mari, V. Pierroz, R. Rubbiani, M. Patra, J. Hess, B. Spingler, J. Schur, L. Oehninger, I. Ott, L. Salassa, S. Ferrari, and G. Gasser,* Chem. Eur. J., 2014, 44, 14421-14436.
    DOI: http://dx.doi.org/10.1002/chem.201402796
  8. Photo-Induced Uncaging of a Specific Re(I) Organometallic Complex in Living Cells
    A. Leonidova, V. Pierroz, R. Rubbiani, Y. Lan. A.G. Schmitz, A. Kaech, R.K.O. Sigel, S. Ferrari, and G. Gasser,* Chem. Sci., 2014, 5, 4044 – 4056.
    DOI: http://dx.doi.org/10.1039/C3SC53550A OPEN ACCESS
  9. Enhanced Cytotoxicity through Conjugation of a “Clickable” Luminescent Re(I) Complex to a Cell-penetrating Lipopeptide
    A. Leonidova, V. Pierroz, L.A. Adams, N. Barlow, S. Ferrari, B. Graham,* and G. Gasser,* ACS Med. Chem. Lett., 2014, 5, 809-814.
    DOI: http://dx.doi.org/10.1021/ml500158
  10. Visible Light-Induced Annhihilation of Tumour Cells Using Novel Platinum-Porphyrin Conjugates
    A. Naik, R. Rubbiani, G. Gasser, B. Spingler,* Angew. Chem. Int. Ed., 2014, 53, 6938-6941.
    DOI: http://dx.doi.org/10.1002.anie.201400533
  11. A Novel, Mercury-Free Synthetic Pathway for Trifluoromethylthio-Subsituted Metallocenes
    J. Hess, S. Konatschnig, S. Morard, V. Pierroz, S. Ferrari, B. Spingler and G. Gasser,* Inorg. Chem., 2014, 53, 3662-3667.
    DOI: http://dx.doi.org/10.1021/ic403169z
  12. Bis(dipyridophenazine)(2-(2′-pyridyl)pyrimidine-4-carboxylic  acid)ruthenium(II) hexafluorophosphate: A Lesson to Stubborness
    T. Joshi,* V. Pierroz, S. Ferrari and G. Gasser,* ChemMedChem, 2014, 9, 1419-1427.
    DOI: http://dx.doi.org/10.1002/cmdc.201400029
    One of the top 10 most cited articles published by ChemMedChem in 2014.
  13. Towards matched Pairs of Porphyrin-Re(I)/99mTc(I) Conjugates that combine Photodynamic Activity with Fluorescence- and Radio-Imaging
    T. Gianferrara,* C. Spagnul, R. Alberto,* G. Gasser, S. Ferrari, V. Pierroz, A. Bergamo, E. Alessio,* ChemMedChem, 2014, 9, 1231-1237.
    DOI: http://dx.doi.org/10.1002/cmdc.201300501
    One of the top 10 most cited articles published by ChemMedChem in 2014.
  14. A Bis(dipyridophenazine)(2-(2′-pyridyl)pyrimidine-4-carboxylic acid) Ruthenium(II)  Complex with Anticancer Action upon Photodeprotection
    T. Joshi,* V. Pierroz, C. Mari, L. Gemperle, S. Ferrari and G. Gasser,* Angew. Chem. Int. Ed., 2014, 53, 2960-2963. Highlighted in Chimia.
    DOI: http://dx.doi.org/10.1002/anie.201309576
  15. A Deadly Organometallic Luminescent Probe: Anticancer Activity of a Re(I) Bisquinoline Complex
    I. Kitanovic, S. Can, H. Alborzina, A. Kitanovic, V. Pierroz, A. Leonidvoa, A. Pinto, B. Spingler, S. Ferrari, R. Molteni, A. Steffen,*, N. Metzler-Nolte,* S. Wölfl* and G. Gasser,* Chem. Eur. J., 2014, 20, 2496-2507. Highlighted in ChemistryViews.
    DOI: http://dx.doi.org/10.1002/chem.20130401
  16. Towards Cancer-Cell Specific Phototoxic Organometallic Rhenium(I) complexes
    A. Leonidova, V. Pierroz, R. Rubbiani, J. Heier, S. Ferrari, and G. Gasser,* Dalton Trans., 2014, 43, 4287-4294 (invited contribution to the themed issue “New Talent: Europe”).
    DOI: http://dx.doi.org/10.1039/C3DT51817E OPEN ACCESS

2013

  1. In Vitro Metabolic Profile and In Vivo Antischistosomal Activity Studies of (η-Praziquantel)Cr(CO)3 Derivatives
    M. Patra, K. Ingram, A. Leonidova, V. Pierroz, S. Ferrari, M.N. Robertson, M.H. Todd, J. Keiser* and G. Gasser,* J. Med. Chem., 2013, 56, 9192-9198.
    DOI: http://dx.doi.org/10.1021/jm401287m
  2. DMSO-mediated Ligand Dissociation: Renaissance for Biological Activity of N-heterocyclic-[Ru(η6-arene)Cl2] Drug Candidates
    M. Patra,* T. Joshi, V. Pierroz, K. Ingram, M. Kaiser, S. Ferrari, B. Spingler, J. Keiser and G. Gasser,* Chem. Eur. J., 2013, 19, 14768-14772.
    DOI: http://dx.doi.org/10.1002/chem.201303341
  3. Synthesis of Ferrocenyl and Ruthenocenyl Thioamide Derivatives Using a Single-Step Three-Component Reaction
    M. Patra,* J. Hess, S. Konatschnig, B. Spingler and G. Gasser,* Organometallics, 2013, 32, 6098–6105.
    DOI: http://dx.doi.org/10.1021/om400715
  4. An Environmentally Benign and Cost-Effective Synthesis of Aminoferrocene and Aminoruthenocene
    A. Leonidova, T. Joshi, D. Nipkow, A. Frei, J.-E. Penner, S. Konatschnig, M. Patra and G. Gasser,* Organometallics, 2013, 32, 2037-204
    DOI: http://dx.doi.org/10.1021/om400009g
  5. Di-Heterometalation of Thiol-Functionalized Peptide Nucleic Acids
    T. Joshi, M. Patra, L. Spiccia, and G. Gasser,* Artifical DNA: PNA & XNA, 2013, 4, 11-18 (invited contribution).
    DOI: http://dx.doi.org/10.416/adna.24019
  6. Synthesis of Stable Peptide Nucleic Acid-Modified Gold Nanoparticles and their Assembly onto Gold Surfaces
    P. Anstaett, Y. Zheng, T. Thai, A.M. Funston, U. Bach* and G. Gasser,* Angew. Chem. Int. Ed., 2013, 52, 4217–4220.
    DOI: http://dx.doi.org/10.1002/anie.210209684
  7. Novel Water-Soluble 99mTc(I)/Re(I)-Porphyrin Conjugates as Potential Multimodal Agents for Molecular Imaging
    C. Spagnul, R. Alberto,* G. Gasser, S. Ferrari, V. Pierroz, A. Bergamo, T. Gianferrara* and E. Alessio, J. Inorg. Biochem., 2013, 122, 57-65.
    DOI: http://dx.doi.org/10.1016/j.jinorgbio.2012.12.016
  8. (η6-Praziquantel)Cr(CO)3 Derivatives with Remarkable In Vitro Anti-schistosomal Activity
    M. Patra, K. Ingram, V. Pierroz, S. Ferrari, B. Spingler, R.B. Gasser, J. Keiser* and G. Gasser,* Chem. Eur. J., 2013, 19, 2232-2235.
    DOI: http://dx.doi.org/10.1002/chem.20120429

2012

  1. Molecular and Cellular Characterization of the Biological Effects of Ruthenium(II) Complexes Incorporating 2-Pyridyl-2-Pyrimidine-4-Carboxylic Acid
    V. Pierroz, T. Joshi, A. Leonidova, C. Mari, J. Schür, I. Ott, L. Spiccia,* S. Ferrari,* and G. Gasser,* J. Am. Chem. Soc., 2012, 134, 20376-20387.
    Highlighted in Chimia and Chemistry in Australia.
    DOI: http://dx.doi.org/10.1021/ja307288s
  2. Ferrocenyl Derivatives of the Anthelminc Praziquantel: Design, Synthesis and Biological Evaluation
    M. Patra, K. Ingram, V. Pierroz, S. Ferrari, B. Spingler, J. Keiser and G. Gasser,* J. Med. Chem., 2012, 55, 8790-8798.
    DOI:  http://dx.doi.org/10.1021/jm301077
  3. Electrochemical, Spectroscopic, Magnetic and Structural Studies of Complexes bearing Ferrocenyl Ligands of N-(3-hydroxypicolinoyl)picolinamide
    G. Gasser,* C. Mari, M. Burkhart, S.J. Green,* J. Ribas, H. Stoeckli-Evans* and J.H.R. Tucker,* New. J. Chem., 2012, 36, 1819-1827.
    DOI: http://dx.doi.org/10.1039/C2NJ40177K
  4. Specific Uptake and Interactions of Peptide Nucleic Acid Derivatives with Biomimetic Membranes
    T. Joshi, G. Gasser,* L.M. Martin* and L. Spiccia,* RSC Adv., 2012, 2, 4703-4712.
    DOI: http://dx.doi.org/10.1039/C2RA20462B
  5. Electrochemiluminescent Monomers for Solid Support Synthesis of Ru(II)-PNA Bioconjugates – Multimodal Biosensing Tools with Enhanced Duplex Stability
    T. Joshi, G.J. Barbante, P.S. Francis, C.F. Hogan, A.M. Bond, G. Gasser* and L. Spiccia,* Inorg. Chem., 2012, 51, 3302-3315.
    DOI: http://dx.doi.org/10.1021/ic202761w
  6. Synthesis, Characterisation and Bioimaging of a New Fluorescent Rhenium-Containing PNA Bioconjugate
    G. Gasser,* A. Pinto, S. Neumann, A.M. Sosniak, M. Seitz, K. Merz, R. Heumann and N. Metzler-Nolte,* Dalton Trans., 2012, 41, 2304-2313.
    DOI: http://dx.doi.org/10.1039/C2DT12114J
  7. Sandwich and Half-Sandwich Derivatives of Platensimycin: Synthesis and Biological Evaluation
    M. Patra, G. Gasser, M. Wenzel, K. Merz, J.E. Bandow and N. Metzler-Nolte,* Organometallics, 2012, 31, 5760–5771.
    DOI: http://dx.doi.org/10.1021/om201146c

2011

  1. Preparation and Biological Evaluation of Di-Hetero-Organometallic-Containing PNA Bioconjugate
    G. Gasser,* S. Neumann, I. Ott, M. Seitz, R. Heumann and N. Metzler-Nolte,* Eur. J. Inorg. Chem., 2011, 5471-5478.
    DOI: http://dx.doi.org/10.10002/ejic.201100734
  2. Synthesis of Optically Active Ferrocene-Containing Platensimycin Derivatives with a C6-C7 Substitution Pattern
    M. Patra, G. Gasser, M. Wenzel, K. Merz, J.E. Bandow N. Metzler-Nolte,* Eur. J. Inorg. Chem., 2011, 3295-3302.
    DOI: http://dx.doi.org/10.1002/ejic.201100497
  3. Towards the Preparation of novel Re/99mTc Tricarbonyl-Containing Peptide Nucleic Acid Bioconjugates
    G. Gasser,* A.M. Sosniak, A. Leonidova, H. Braband and N. Metzler-Nolte,* Aust. J. Chem., 2011, 64, 1-8 (invited contribution).
    DOI: http://dx.doi.org/10.1071/CH11010

2010

  1. Synthesis and Biological Evaluation of Ferrocene-containing Bioorganometallics Inspired by the Antibiotic Platensimycin Lead Structure
    M. Patra, G. Gasser, M. Wenzel, K. Merz, J.E. Bandow and N. Metzler-Nolte,* Organometallics, 2010, 29, 4312-4319.
    DOI: http://dx.doi.org/10.1021/om100614c
  2. Preparation, 99mTc-Labeling and Biodistribution Studies of a PNA Oligomer Containing a New Ligand Derivative of 2,2’-Dipicolylamine
    G. Gasser,* K. Jäger, M. Zenker, R. Bergmann, J. Steinbach, H. Stephan* and N. Metzler-Nolte,* J. Inorg. Biochem., 2010, 104, 1133-1140.
    DOI: http://dx.doi.org/10.1016/j.jinorgbio.2010.06.011
  3. Sequential Insertion of three Different Organometallics into a Versatile Building Block Containing a PNA Backbone
    M. Patra, G. Gasser,* D. Bobukhov, K. Merz, A.V. Shtemenko and N. Metzler-Nolte,* Dalton Trans., 2010, 39, 5617-5619.
    DOI: http://dx.doi.org/10.1039/c003589J
  4. Synthesis and Complexation Properties of Novel Triazoyl-Based Ferrocenyl Ligands
    G. Gasser,* J.D. Carr, S.J. Coles, S.J. Green, M.B. Hursthouse, S.M. Cafferkey, H. Stoeckli-Evans, and J.H.R. Tucker,* J. Organomet. Chem., 2010, 695, 249-255.
    DOI: http://dx.doi.org/10.1016/j.jorganchem.2009.10.004

2009

  1. Thermal Melting Studies of Alkyne and Ferrocene-containing PNA Bioconjugates
    A. Sosniak, G. Gasser and N. Metzler-Nolte,* Org. Biomol. Chem., 2009, 7, 4992 – 5000.
    DOI: http://dx.doi.org/10.1039/b913964h
  2. Synthesis and Biological Evaluation of Chromium Bioorganometallics Based on the Antibiotic Platensimycin Lead Structure
    M. Patra, G. Gasser, K. Merz, I. Ott, J.E. Bandow and N. Metzler-Nolte,* ChemMedChem, 2009, 4, 1930-1938.
    DOI: http://dx.doi.org/10.1002/cmdc.200900347
  3. “Four-Potential” Ferrocene Labelling of PNA Oligomers via Click Chemistry
    N. Hüsken, G. Gasser, S.D. Köster and N. Metzler-Nolbe,* Bioconjugate Chem., 2009, 20, 1578–1586.
    DOI: http://dx.doi.org/10.1021/bc9001272
  4. Synthesis and Characterisation of Hetero-Bimetallic Organometallic Phenylalanine and PNA Monomer Derivatives
    G. Gasser, O. Brosch, A. Ewers, T. Weyhermüller and N. Metzler-Nolte,* Dalton Trans., 2009, 4310-4317. Selected as HOT ARTICLE
    DOI: http://dx.doi.org/10.1039/b819169g
  5. Synthesis, Spectroscopic Properties and Electrochemical Oxidation of RuII Complexes Attached to a Peptide Nucleic Acid Monomer Backbone
    N. Nickita, G. Gasser, A.M. Bond and L. Spiccia,* Eur. J. Inorg. Chem., 2009, 14, 2179-2186.
    DOI: http://dx.doi.org/10.1002/ejic.200801259
  6. Synthesis and Characterisation of Dicobalthexacarbonyl-Alkyne Amino Acid, Peptide and PNA Monomer Derivatives
    G. Gasser, M.A. Neukamm, A. Ewers, O. Brosch, T. Weyhermüller and N. Metzler-Nolte,* Inorg. Chem., 2009, 48, 3157-3166.
    DOI: http://dx.doi.org/10.1021/ic900013r
  7. Binding of HIV-1TAR mRNA to a Peptide Nucleic Acid Oligomer and its Conjugates with Metal-Ion-Binding Multidentate Ligands
    M.J. Belousoff, G. Gasser, B. Graham, Y. Tor and L. Spiccia,* J. Biol. Inorg. Chem., 2009, 14, 287-300.
    DOI: http://dx.doi.org/10.1007/s00775-008-0448-6
  8. Ruthenium(II) Complexes Incorporating 2-Pyridyl-2-Pyrimidine-4-Carboxylic acid
    N. Nickita, G. Gasser, P. Pearson, L.Y. Goh, A.M. Bond, G.B. Deacon and L. Spiccia,* Inorg. Chem., 2009, 48, 68-81.
    DOI: http://dx.doi.org/10.1021/ic800972x

2008

  1. Spectroscopic and Electrochemical Studies of Ferrocenyl Triazole Amino Acid and Peptide Bioconjugates Synthesized by Click Chemistry
    S. D. Köster, J. Diettrich, G. Gasser N. Hüsken, I.C. Henao Castañeda, J.L. Jios, C.O. Della Védova, and N. Metzler-Nolte,* Organometallics, 2008, 27,6326–6332.
    DOI: http://dx.doi.org/10.1021/om800639m
  2. Synthesis of Organometallic PNA Oligomers by Click Chemistry
    G. Gasser, N. Hüsken, S.D. Köster and N. Metzler-Nolte,* Chem. Commun., 2008, 3675-3677.
    DOI: http://dx.doi.org/10.1039/b805369c
  3. Synthesis of a Ferrocenyl Uracil PNA Monomer for Insertion into PNA Sequences
    G. Gasser and L. Spiccia,* J. Organomet. Chem., 2008, 693, 2478-2482.
    DOI: http://dx.doi.org/10.1016/j.jorganchem.2008.05.009
  4. Synthesis, Copper(II) Complexation, 64Cu-Labeling and Bioconjugation of a New Bis(2-pyridylmethyl) Derivative of 1,4,7-triazacyclonane
    G. Gasser, L. Tjioe, B. Graham,* M.J. Belousoff, S. Juran, J.-U. Künstler, M. Walther, R. Bergmann, H. Stephan* and L. Spiccia,* Bioconjugate Chem., 2008, 19, 719-730.
    DOI: http://dx.doi.org/10.1021/bc700396e

2007

  1. Synthesis, Structure, Spectroscopic Properties and Electrochemical Oxidation of Ruthenium(II) Complexes Incorporating Monocarboxylate Bipyridine Ligands
    N. Nickita, M.J. Belousoff, A.I. Bhatt, A.M. Bond, G.B. Deacon, G. Gasser and L. Spiccia,* Inorg. Chem., 2007, 46, 8638-8651.
    DOI: http://dx.doi.org/10.1021/ic700796m
  2. Products of Hydrolysis of (Ferrocenylmethyl)­trimethyl­ammonium Iodide: Synthesis of Hydroxymethylferrocene and Bis(ferrocenylmethyl) Ether
    G. Gasser, A.J. Fischmann, C.M. Forsyth and L. Spiccia,* J. Organomet. Chem., 2007, 692, 3835-3840.
    DOI: http://dx.doi.org/10.1016/j.jorganchem.2007.05.020
  3. Binding of Nitrate to a CuII-Cyclen Complex Bearing a Ferrocenyl Pendant: Synthesis, Solid State X-ray Structure and Solution Phase Electrochemical and Spectrophotometric Studies
    G. Gasser, M.J. Belousoff, A.M. Bond and L. Spiccia,* Inorg. Chem., 2007, 46, 3876-3888.
    DOI: http://dx.doi.org/10.1021/ic061622+
  4. Recognition of Thymine and Related Nucleosides by a ZnII-Cyclen Complex Bearing a Ferrocenyl Pendant
    G. Gasser, M.J. Belousoff, A.M. Bond, Z. Kosowski and L. Spiccia,* Inorg. Chem. 2007, 46, 1665-1674.
    DOI: http://dx.doi.org/10.1021/ic061902p

2006

  1. Facile Synthesis and Detailed Characterization of a New Ferrocenyl Uracil Peptide Nucleic Acid Monomer
    G. Gasser, M.J. Belousoff, A.M. Bond and L. Spiccia,* J. Org. Chem., 2006, 71, 7565-7573.
    DOI: http://dx.doi.org/10.1021/jo060868t

2005

  1. Selective Electrochemical Sensing of Acidic Organic Molecules via a Novel Guest-to-Host Proton Transfer Reaction
    H. Miyaji, G. Gasser, S.J. Green, Y. Molard, S.M. Strawbridge and J.H.R. Tucker,* Chem. Commun., 2005, 5355-5357.
    DOI: http://dx.doi.org/10.1039/b510513g

2004

  1. A Heterodifunctionalised Ferrocene Derivative that Self-assembles in Solution through Complementary Hydrogen-Bonding Interactions
    H. Miyaji, M. Dudic, G. Gasser, S.J. Green, G. Labat, N. Moran, I. Prokes, H. Stoeckli-Evans, S.M. Strawbridge and J.H.R. Tucker,* Dalton Trans., 2004, 18, 2831-2832.
    DOI: http://dx.doi.org/10.1039/B409533B
  2. Binding and Electrochemical Recognition of Barbiturate and Urea Derivatives by a Regioisomeric Series of Hydrogen-Bonding Ferrocene Receptors
    J. Westwood, S.J. Coles, S.R. Collinson, G. Gasser, S.J. Green, M.B. Hursthouse, M.E. Light and J.H.R. Tucker,* Organometallics, 2004, 23, 946-951.
    DOI: http://dx.doi.org/10.1021/om034217o