2024
- Synthesis, Characterization and Biological Evaluation of Novel [M(η6-arene)2]+ (M = Re, 99mTc) Hosted Terpyridines and Copper Complexes Thereof
J. Csucker, M. Scarpi-Luttenauer, P. Mesdom, S. Hidalgo, O. Blacque, G. Gasser,* and R. Alberto,* Inorg. Chem., 2024, 63, 18154-18161.
DOI: https://doi.org/10.1021/acs.inorgchem.4c03018 OPEN ACCESS - Synthesis and Anticancer Properties of Heterobimetallic Fe(II)/Pd(II) Complexes bearing Different Butadienyl Fragment
E. Bortolamiol, M. Dalla Pozza, N. Demitri, F. Rizzolio, F. Visentin,* G. Gasser* and T. Scattolin,* Eur. J. Inorg. Chem., 2024, e202400322.
DOI: https://doi.org/10.1002/ejic.202400322 OPEN ACCESS - A Toolbox for Enzymatic Modification of Nucleic Acids with Photosensitizers for Photodynamic Therapy
G. Niogret, C. Chériaux, F. Bonhomme, F. Levi-Acobas, C. Figliola, G. Ulrich, G. Gasser,* and M. Hollenstein,* RSC Chem. Biol., 2024, 5, 841-852.
DOI: https://doi.org/10.1039/D4CB00103F OPEN ACCESS - Exploring the Potential of Ruthenium(II)-Phosphine-Mercapto Complexes as New Anticancer Agent
M.V. Palmeira-Mello, A.R. Costa, L.P. de Oliveira, O. Blacque, G. Gasser,* and A.A. Batista,* Dalton Trans., 2024, 53, 10947-10960.
DOI: https://doi.org/10.1039/D4DT01191K - Aminocarbyne-Alkyne Coupling in Diruthenium Complexes: Exploring the Anticancer Potential of the Resulting Vinyliminium Complexes and Comparison with Diiron Homologues
B. Bertoncini, Z. Xiao, S. Zacchini, L. Biancalana,* G. Gasser,* and Fabio Marchetti,* Inorg. Chem., 2024, 63, 12485-12497.
DOI: https://doi.org/10.1021/acs.inorgchem.4c01119 - An Iridium(III)-Based Photosensitizer Disrupting the Mitochondrial Respiratory Chain Induces Ferritinophagy-Mediated Immunogenic Cell Death
T. Feng, Z. Tang, J. Karges, J. Shu, K. Xiong, C. Jin, Y. Chen, G. Gasser,*, L. Ji, and H. Chao,* Chem. Sci., 2024, 15, 6752-6762.
DOI: https://doi.org/10.1039/D4SC01214C OPEN ACCESS - A G-quadruplex-binding Platinum Complex induces Cancer Cell Mitochondrial Dysfunction in vitro and in vivo independently of Reactive Oxygen Species Induction
K. Kuang, C. Li, F. Maksut, D. Ghosh, R. Vinck, M. Wang, J. Poupon, R. Xiang, W. Li, F. Li, J. Du, M.-P. Teulade-Fichou, G. Gasser, S. Bombard* and T. Jia,* J. Biomed. Sci., 2024, 31, 50.
DOI: https://doi.org/10.1186/s12929-024-01041-6 OPEN ACCESS - Antifungal and Antiparasitic Activity of Novel Metallocene-containing Fluconazole Derivatives
Y. Lin, G. Scalese, C.A. Bulman, R. Vinck, O. Blacque, M. Paulino, A. Ballesteros-Casallas, L. Pérez Díaz, G. Salinas, M. Mitreva,* T. Weil,* K. Cariou,* J.A. Sakanari,* D. Gambino,* and G. Gasser,* ACS Infect. Dis., 2024, 10, 938-950.
DOI: https://doi.org/10.1021/acsinfecdis.3c00577
2023
- Red-Light Responsive Polypeptoid Nano-Assemblies Containing a Ruthenium(II) Polypyridyl Complex with Synergistically Enhanced Drug Release and ROS Generation for Anticancer Phototherapy
Y. Ma, Z. Zhihua, F. Sun, P. Mesdom, X. Ji, P. Burckel, G. Gasser, M.-H. Li,* Biomacromolecules, 2023, 24, 5940-5950.
DOI: https://doi.org/10.1021/acs.biomac.3c00949 - Discovery of New Broad-Spectrum Anti-Infective Agents Based on Bioorganometallic Chemistry
Y. Lin, H. Jung, C.A. Bulman, J. Ng, R. Vinck, C. O’Beirne, S. Zhong, M.S. Moser, N. Tricoche, R. Peguero, R. Li, J.F. Urban Jr, P. Le Pape, F. Pagniez, M. Moretto, T. Weil,* S. Lustigman,* K. Cariou,* M. Mitreva,* J.A. Sakanari* and G. Gasser,* J. Med. Chem., 2023, 6, 15867-15882.
DOI: https://doi.org/10.1021/acs.jmedchem.3c01333 - BASHY Dyes Are Highly Efficient Lipid Droplet-targeting Photosensitizers That Induce Ferroptosis Through Lipid Peroxidation
M.J.S.A. Silva, Y. Zhang, R. Vinck, F.M.F. Santos, J.P.M. António, L. Gourdon-Grünewaldt, C. Zaouter, A. Castonguay, S.A. Patten, K. Cariou, F. Boscá, F. Nájera, J.F. Arteaga, G. Gasser,* U. Pischel* and P.M.P. Gois,* Bioconjugate Chem., 2023, 34, 2337-2344.
DOI: https://doi.org/10.1021/acs.bioconjchem.3c00449 - Facilitated Synthetic Access to Boronic Acid-Modified Nucleoside Triphosphates and Compatibility with Enzymatic DNA Synthesis
G. Niogret, P. Röthlisberger, F. Levi-Acobas, F. Bonhomme, G. Gasser and M. Hollenstein,* Synlett, 2023, 35, 677-683.
DOI: https://doi.org/10.1055/a-2212-7704 - Increasing the π-expansive Ligands in Ru(II) Polypyridyl Complexes: Synthesis, Characterisation and Biological Evaluation for Photodynamic Therapy Applications
M. Dalla Pozza, P. Mesdom, A. Abdullrahman, T.D. Prieto Otoya, P. Arnoux, C. Frochot, B. Saubaméa, G. Niogret, M. Hollenstein, P. Burckel, J.P. Hall, C.J. Cardin, and G. Gasser,* Inorg. Chem., 2023, 62, 18510-18523.
DOI: https://doi.org/10.1021/acs.inorgchem.3c02606
- Compatibility of Nucleotides Modified with Benzene Bioisosteres and Substituted Cubanes with Enzymatic DNA Synthesis and Aptamer Functionalization
G. Niogret, A. Bouvier-Müller, C. Figazzolo, J. Joyce, F. Bonhomme, P. England, O. Mayboroda, R. Pellarin, G. Gasser, J.H.R. Tucker, J.A. Tanner, P. Savage, and M. Hollenstein,* ChemBioChem, 2023, 24, e202300539.
DOI: http://dx.doi.org/10.1002/cbic.202300539 OPEN ACCESS - Ru(II)/Os(II)-based Carbonic Anhydrase Inhibitors as Photodynamic Therapy Photosensitizers for the Treatment of Hypoxic Tumours
Y. Wang, P. Mesdom, K. Purkait, B. Saubaméa, P. Burckel, K. Cariou,* T. Rossel,* and G. Gasser,* Chem. Sci, 2023, 14, 11749-11760.
DOI: https://doi.org/10.1039/D3SC03932C OPEN ACCESS - Towards Copper(I) Clusters for Photo-Induced Oxidation of Biological Thiols in Living Cells
L. Gourdon-Grünewaldt, O. Blacque, G. Gasser,* and K. Cariou,* ChemBioChem, 2023, 24, e202300496.
DOI: https://doi.org/10.1002/cbic.202300496 OPEN ACCESS - In situ Bioconjugation of a Maleimide-Functionalized Ruthenium-based Photosensitizer to Albumin for Photodynamic Therapy
R. Vinck,* O. Dömötör, J. Karges, M. Jakubaszek, J. Séguin, M. Tharaud, V. Guérineau, K. Cariou, N. Mignet, E.A. Enyedy, and G. Gasser,* Inorg. Chem., 2023, 62, 15510-15526.
DOI: https://doi.org/10.1021/acs.inorgchem.3c01984
- Ru(II)-Cyanine Complexes as Promising Photodynamic Photosensitizers for the Treatment of Hypoxic Tumours with Highly Penetrating 770 nm Near-Infrared Light
A. Gandioso, E. Izquierdo-García, P. Mesdom, P. Arnoux, N. Demeubayeva, P. Burckel, B. Saubaméa, C. Frochot, V. Marchán* and G. Gasser,* Chem. Eur. J., 2023, e202301742.
DOI: http://dx.doi.org/10.1002/chem.202301742 OPEN ACCESS - Towards Ruthenium(II)-Rhenium(I) Binuclear Complexes as Photosensitizers for Photodynamic Therapy
Y. Wang, P.S. Felder, P. Mesdom, O. Blacque, T.L. Mindt, K. Cariou,* and G. Gasser,* ChemBioChem, 2023, 24, e202300467.
DOI: https://doi.org/10.1002/cbic.202300467 OPEN ACCESS - Rhenium(I) Tricarbonyl Complexes of 1,10 Phenanthroline Derivatives with Unexpectedly High Cytotoxicity
L.E. Enslin, K. Purkait, M. Dalla Pozza, B. Saubamea, P. Mesdom, H.G. Visser,* G. Gasser* and M. Schutte-Smith,* Inorg. Chem., 2023, 62,1 2237-12251.
DOI: https://doi.org/10.1021/acs.inorgchem.3c00730 - Towards Platinum(II) Complexes for in cellulo Applications: Synthesis, Characterization, Biological and Catalytic Evaluation
L. Gourdon, M. Bakija, L. Wild, G. Gasser, S. Kirin* and K. Cariou,* Helv. Chim. Acta., 2023, 106, e202300078 (special issue in honour of Prof. Roger Alberto).
DOI: https://doi.org/10.1002/hlca.202300078 OPEN ACCESS - A Near-Infrared Light-Activatable Ru(II)-Coumarin Photodynamic Therapy Photosensitizer Active under Hypoxic Conditions
E. Ortega-Forte, A. Rovira, M. López Corrales, A Hernández García, F.J. Ballester, E. Izquierdo-García, M. Jordà-Redondo, M. Bosch, S. Nonell, M. Dolores Santana, J. Ruiz,* V. Marchán* and G. Gasser,* Chem. Sci., 2023, 14, 7170-7184.
DOI: https://doi.org/10.1039/D3SC01844 OPEN ACCESS - Synthesis, Characterisation and Biological Evaluation of Homo- and Heterobimetallic Re(I) Complexes with a 1,2,3-Triazolyl-Pyridine Chelating Moiety
S. Jakopec, L. Gourdon-Grünewald, I. Čipor, A. Meščić Macan, B. Perić, I. Piantanida, K. Cariou, G. Gasser,* S.I. Kirin* and S. Raić-Malić,* Dalton Trans., 2023, 52, 9482-9498.
DOI: https://doi.org/10.1039/D3DT01070H - A Novel Near-IR Absorbing Ruthenium(II) Complex and its Cetuximab Bioconjugates as Targeted Photosensitizers for Photodynamic Therapy
M. Martínez-Alonso, A. Gandioso, C. Thibaudeau, X. Qin, P. Arnoux, N. Demeubayeva, V. Guérineau, C. Frochot, A.C. Jung,* C. Gaiddon,* and G. Gasser,* ChemBioChem, 2023, 24, e202300203.
DOI: http://dx.doi.org/10.1002/cbic.202300203 OPEN ACCESS - The Beneficial Effect of Cyclohexyl Substituent on the In Vitro Anticancer Activity of Diiron Vinyliminium Complexes
S. Benetti, M. Dalla Pozza, L. Biancalana, S. Zacchini, G. Gasser* and F. Marchetti,* Dalton Trans., 2023, 52, 5724-5741.
DOI: https://doi.org/10.1039/D3DT00186E
- Structurally Simple Osmium(II) Polypyridyl Complexes as Photosensitizers for Photodynamic Therapy in the Near Infrared
A. Mani, T. Feng, A. Gandioso, R. Vinck, A. Notaro, L. Gourdon, P. Burckel, B. Saubaméa, O. Blacque, K. Cariou, J.-E. Belgaied, H. Chao,* and G. Gasser,* Angew. Chem. Int. Ed., 2023, 62, e202218347.
DOI: https://doi.org/10.1002/anie.202218347K OPEN ACCESS - A Mitochondria-Localized Iridium(III) Photosensitizer for Effective Two-Photon Photodynamic Immunotherapy Against Melanoma
L. Wang, J. Karges, F. Wei, L. Xie, Z. Chen, G. Gasser,* L. Ji, and H. Chao,* Chem. Sci., 2023, 14, 1461-1471.
DOI: https://doi.org/10.1039/D2SC06675K OPEN ACCESS - N-Metallocenyl Ynamides: Preparation, Oxidative Functionalization and Synthesis of an ansa[3]-Ferrocenylamide
C. Mahe, O. Blacque, G. Gasser, V. Gandon and K. Cariou,* Org. Lett., 2023, 25, 4624–4629.
DOI: https://doi.org/10.1021/acs.orglett.2c04169 - Multifunctional Organometallic Compounds for the Treatment of Chagas Disease: Re(I) Tricarbonyl Compounds with Two Different Bioactive Ligand
M. Soba, G. Scalese, F. Casuriaga, N. Pérez,, N. Veiga, G.A. Echeverría, O.E. Piro, R. Faccio, L. Pérez-Díaz, G. Gasser, I. Machado* and D. Gambino,* Dalton Trans., 2023, 52, 1623-1641.
DOI: https://doi.org/10.1039/D2DT03869B - Polymeric Encapsulation of a Novel Ruthenium(II) Polypyridyl Complex: From Synthesis to in vivo Studies against High-Grade Epithelial Ovarian Cancer
J.P.M. António, A. Gandioso F. Nemati, N. Soliman, R. Vinck, F. Sun, C. Robert, P. Burckel, D. Decaudin, C.M. Thomas* and G. Gasser,* Chem. Sci., 2023, 14, 362-371.
DOI: https://doi.org/10.1039/D2SC05693C OPEN ACCESS - Towards Selective Delivery of a Ruthenium(II) Polypyridyl Complex-Containing Bombesin Conjugate into Cancer Cells
M.J.S.A. Silva, R. Vinck, Y. Wang, B. Saubaméa, M. Tharaud, E. Dominguez-Jurado, J. Karges, P.M.P. Gois* and G. Gasser,* ChemBioChem., 2023, 24, e202200647.
DOI: http://dx.doi.org/10.1002/cbic.202200647 - Polymersomes with Bright Far-Red/Near-Infrared Emission and Reactive Oxygen Species Generation
Z. Zhang, H. Chen, Y. Wang, N. Zhang, S. Trépout, B.Z. Tang, G. Gasser, M.-H. Li,* Macromol. Rapid. Commun., 2023, 44, 2200716.
DOI: https://doi.org/10.1002/marc.202200716
2022
- Red-Absorbing Ru(II) Polypyridyl Complexes with Biotin Targeting Spontaneously Assemble into Nanoparticles in Biological Media
R. Vinck, A. Gandioso, P. Burckel, B. Saubaméa, K. Cariou and G. Gasser,* Inorg. Chem., 2022, 61, 13576-13585.
DOI: https://doi.org/10.1021/acs.inorgchem.2c02214 - Ruthenium(II) Polypyridyl Complexes Containing Simple Dioxo Ligands: a Structure-Activity Relationship Study Shows the Importance of the Charge
A. Gandioso, A. Vidal, P. Burckel, G. Gasser* and E. Alessio,* ChemBioChem, 2022, 23d, e202200398.
DOI: http://dx.doi.org/10.1002/cbic.202200398 OPEN ACCESS - Organometallic Derivatives of Decoquinate targeted towards Toxoplasma gondii
H.D. Betts, Y.C. Ong, N. Anghel, S. Keller, J. Karges, N. Voutsara, J. Müller, E. Manoury, O. Blacque, K. Cariou, A. Hemphill,* G. Gasser,* Organometallics, 2022, 41, 2035-2041.
DOI: https://doi.org/10.1021/acs.organomet.2c00204 - Is Antitumor Pt(IV) Complex Containing Two Axial Lonidamine Ligands a True Dual- or Multi-Action Prodrug?
J. Kasparkova, H. Kostrhunova, V. Novohradsky, G. Zhu, E.R. Milaeva, A.A. Shtill, R. Vinck, G. Gasser, V. Brabec* and A.A. Nazarov,* Metallomics, 2022, 14, mfac048.
DOI: https://doi.org/10.1093/mtomcs/mfac048 - Photo-Decaging of A Mitochondria-Localized Iridium(III) Endoperoxide Complex for Two-Photon Photoactivated Therapy under Hypoxia
S. Kuang, F. Wei, J. Karges, L. Ke, K. Xiong, X. Liao, G. Gasser,* L. Ji, and H. Chao,* J. Am. Chem. Soc., 2022, 144, 4091-4101.
DOI: https://doi.org/10.1021/jacs.1c13137 - Tethering Carbohydrates to the Vinyliminium Ligand of Antiproliferative Organometallic Diiron Complexes
S. Schoch, D. Iacopini, M. Dalla Pozza, S. Di Pietro, G. Gasser,* V. Di Bussolo,* F. Marchetti,* Organometallics, 2022, 41, 514-526.
DOI: https://pubs.acs.org/doi/10.1021/acs.organomet.1c00519 - A Ruthenium-Oligonucleotide Bioconjugated Photosensitizing Aptamer for Cancer Cell Specific Photodynamic Therapy
L.K. McKenzie, M. Flamme, P.S. Felder, J. Karges, F. Bonhomme, A. Gandioso, C. Malosse, G. Gasser,* and M. Hollenstein,* RSC Chem. Biol., 2022, 3, 85-95.
DOI: http://dx.doi.org/10.1039/D1CB00146A OPEN ACCESS
2021
- Metallodrug Profiling against SARS-CoV-2 Target Proteins Identifies Highly Potent Inhibitors of the Spike/ACE2 Interaction and the Papain-like Protease PLpro
M. Gil-Moles, S. Türck, U. Basu, A. Pettenuzzo, S. Bhattacharya, A. Rajan, X. Ma, R. Büssing, J. Wölker, H. Burmeister, H. Hoffmeister, P. Schneeberg, A. Prause, P. Lippmann, J. Kusi-Nimarko, S. Hassell-Hart, A. McGown, D. Guest, Y. Lin, A. Notaro, R. Vinck, J. Karges, K. Cariou, K. Peng, X. Qin, X. Wang J. Skiba, Ł. Szczupak, K. Kowalski, U. Schatzschneider, C. Hemmert, H. Gornitzka, E.R. Milaeva, A.A. Nazarov, G. Gasser, J. Spencer; L. Ronconi, U. Kortz, J. Cinatl, D. Bojkova and I. Ott,* Chem. Eur. J., 2021, 27, 17928-17940.
DOI: https://doi.org/10.1002/chem.202103258 OPEN ACCESS - Physical, Spectroscopic, and Biological Properties of Ruthenium and Osmium Photosensitizers Bearing Diversely Substituted 4,4′-di(styryl)-2,2′-bipyridine Ligand
R. Vinck, J. Karges, M. Tharaud, K. Cariou and G. Gasser,* Dalton Trans., 2021, 50, 14629-14639.
DOI: http://dx.doi.org/10.1039/D1DT02083H - Synthesis and Biological Evaluation of Metallocene-tethered Peptidyl inhibitors of CDC25
S. Roy, L. Rangasamy, A. Nouar, C. Koenig, V. Pierroz, S. Kaeppeli, S. Ferrari,* M. Patra* and G. Gasser,* Organometallics, 2021, 40, 2716-2723.
DOI: https://doi.org/10.1021/acs.organomet.1c00345 - In vivo Active Organometallic-containing Antimycotic Agents
R. Rubbiani,* T. Weil,* N. Tocci, L. Mastrobuoni, S. Jeger, M. Moretto, J. Ng, Y. Lin J. Hess, S. Ferrari, A. Kaech, L. Young, J. Spencer, A. L. Moore, K. Cariou,* R. Giorgia, L. Romani, M. Pariano and G. Gasser,* RSC Chem. Biol., 2021, 2, 1263-1273.
DOI: https://doi.org/10.1039/D1CB00123J OPEN ACCESS - Development and in vitro Evaluation of New Bifunctional 89Zr-chelators Based on the 6-Amino-1,4-diazepane Scaffold for Immuno-PET Application
B. Klasen, D. Lemcke, T.L. Mindt, G. Gasser, and F. Rösch,* Nucl. Med. Biol.., 2021, 102-103, 12-23.
DOI: https://doi.org/10.1016/j.nucmedbio.2021.06.007 - Cis-locked Ru(II)-dmso Precursors for the Microwave-Assisted Synthesis of bis-Heteroleptic Polypyridyl Compounds
A. Vidal, R. Calligaro, G. Gasser, R. Alberto, G. Balducci, and E. Alessio,* Inorg. Chem., 2021, 60, 7180-7195.
DOI: https://pubs.acs.org/doi/10.1021/acs.inorgchem.1c00240 - Ru(II) Polypyridine Complex Functionalized Mesoporous Silica Nanoparticles as Photosensitizers for Cancer Targeted Photodynamic Therapy
J. Karges, D. Díaz-García, S. Prashar, S. Gómez-Ruiz* and G. Gasser,* ACS Appl. Bio. Mater., 2021, 4, 4394-4405.
DOI: https://pubs.acs.org/doi/10.1021/acsabm.1c00151 - Polymeric Encapsulation of a Ru(II)-based Photosensitizer for Folate Targeted Photodynamic Therapy of Drug Resistant Cancers
J. Karges, M. Tharaud and G. Gasser,* J. Med. Chem., 2021, 64, 4612-4622.
DOI: http://dx.doi.org/10.1021/acs.jmedchem.0c02006 - Amino-Sulfhydryl Stapling on Peptides and Proteins Using Bifunctional NHS-Activated Acrylamides
M.J.S.A. Silva, H. Faustino, J.A.S. Coelho, I. Compañón, F. Corzana, G. Gasser, and P.M.P. Gois,* Angew. Chem. Int. Ed., 2021, 10850-10857.
DOI: https://doi.org/10.1002/anie.20201693 - Probing Substituent Effects in Bulky Analogues of (+)-JQ1
S. Hassell-Hart, S. Picaud, R. Lengacher, J. Csucker, R. Milet, G. Gasser, R. Alberto, H. Maple, Ro. Felix, Z.J. Leśnikowski, H.J.S. Stewart, T.J. Chevassut, S. Morley, P. Filippakopoulos,* J. Spencer,* Helv. Chim. Acta, 2021, 104, e2000214.
DOI: https://doi.org/10.1002/hlca.202000214 - 1- and 2-Photon Phototherapeutic Effects of Novel Ru(II) Polypyridine Complexes in the Hypoxic Centre of Large Multicellular Tumour Spheroids and Tumour-Bearing Mice
J. Karges, S. Kuang, Y.C. Ong, H. Chao,* and G. Gasser,* Chem. Eur. J., 2021, 27, 362-367.
DOI: http://dx.doi.org/10.1002/chem.202003486 - Highly Cytotoxic Copper(II) Terpyridine Complexes as Anticancer Drug Candidates
J. Karges, K. Xiong, O. Blacque, H. Chao* and G. Gasser,* Inorg. Chim. Acta, 2021, 516, 120137. (invited contribution for the special issue in honour of Prof. Tara P. Dasgupta).
DOI: https://doi.org/10.1016/j.ica.2020.120137 - Head to head comparison of DFO* and DFO chelators: selection of the best candidate for clinical 89Zr-immuno-PET
M. Chomet, M. Schreurs, M.J. Bolijn, M. Verlaan, W. Beaino, K. Brown, A.J. Poot, A.D. Windhorst, H. Gill, J. Mari, S. Williams, J. Cowell, G. Gasser, T.L. Mindt, G.A.M.S van Dongen, D.J. Vugts,* Eur. J. Nucl. Med. Mol. Imag., 2021, DOI: 10.1007/s00259-020-05002-7.
DOI: https://doi.org/10.1007/s00259-020-05002-7 OPEN ACCESS
2020
- Polymeric Encapsulation of Ruthenium Polypyridine Complexes for Tumor Targeted 1- and 2-Photon Photodynamic Therapy
J. Karges, J. Li, L. Zeng, H. Chao,* and G. Gasser,* ACS Appl. Mat. Interfaces, 2020, 12, 54433-54444.
DOI: https://doi.org/10.1021/acsami.0c16119 - Studying the Cellular Distribution of Highly Phototoxic Platinated Metalloporphyrins by Isotope Labelling
R. Rubbiani, W. Wu, A. Naik, M. Larocca, L. Schneider, R. Padrutt, V. Babu, C. König, D. Hinger, C. Maake, S. Ferrari, G. Gasser and B. Spingler* Chem. Commun, 2020, 56, 14373-14376.
DOI: https://doi.org/10.1039/D0CC05196A
- Encapsulation of a Ru(II) Polypyridyl Complex into Polylactide Nanoparticles for Antimicrobial Photodynamic Therapy
N. Soliman, V. Sol, T.-S. Ouk, C.M. Thomas,* and G. Gasser,* Pharmaceutics, 2020, 12, 961 (invited contribution for the special issue on Metal-Based Drugs and Nanostructured Materials: New Trends in Bioactive Systems).
DOI: http://dx.doi.org/10.3390/pharmaceutics12100961 OPEN ACCESS - Multidisciplinary Preclinical Investigations on Three Oxamniquine Analogues as Novel Drug Candidates for Schistosomiasis
V. Buchter, Y.C. Ong, F. Mouvet, A. Ladaycia, E. Lepeltier, U. Rothlisberger,* J. Keiser,* and G. Gasser,* Chem. Eur. J., 2020, 26, 15232-15241.
DOI: http://dx.doi.org/10.1002/chem.202002856 - Enzymatic Formation of an Artificial Base Pair using a Modified Adenine Triphosphate
M. Flamme, P. Röthlisberger, F. Levi-Acobas, M. Chawla, R. Oliva, L. Cavallo, G. Gasser, P. Marlière, P. Herdewijn and M. Hollenstein,* ACS Chem. Biol., 2020, 15, 2872-2884.
DOI: http://dx.doi.org/10.1021/acschembio.0c00396 - Effect of Metal Shielding on the Enzymatic Construction of Artificial Base Pairs
M. Flamme, F. Levi-Acobas, S. Hensel, S. Naskar, P. Röthlisberger, I. Sarac, G. Gasser, J. Müller, and M. Hollenstein,* ChemBioChem, 2020, 21, 1-13 (invited contribution for the issue on the 1st workshop on Metals in Medicine in Paris).
DOI: http://dx.doi.org/10.1002/cbic.202000402 - Radiolabelling of the Octadentate Chelators DFO* and oxoDFO* with Zirconium-89 and Gallium-68
M. Brandt, J. Cowell, M.L. Aulsebrook, G. Gasser* and T.L. Mindt* J. Biol. Inorg. Chem., 2020, 25, 789-796.
DOI: http://dx.doi.org/10.1007/s00775-020-01800-4 - Synthesis, Characterisation and Biological Evaluation of the Polymeric Encapsulation of a Ru(II) Polypyridine Complex with Pluronic F-127/Poloxamer 407 for Photodynamic Therapy Applications
J. Karges, H. Chao,* and G. Gasser,* Eur. J. Inorg. Chem., 2020, 34, 3242-3248 (invited contribution for the special issue for the 44th International Conference on Coordination Chemistry in Rimini).
DOI: http://dx.doi.org/10.1002/ejic.202000545 - Rationally Designed Ruthenium Complexes for 1- and 2-Photon Photodynamic Therapy
J. Karges, S. Kuang, F. Maschietto, O. Blacque, I. Ciofini, H. Chao,* and G. Gasser,* Nature Commmun., 2020, 11, 3262.
DOI: https://www.nature.com/articles/s41467-020-16993-0 OPEN ACCESS - Increased Lipophilicity of Halogenated Ruthenium(II) Polypyridyl Complexes Leads to Decreased Phototoxicity in vitro When Used as Photosensitizers for Photodynamic Therapy
S. Roy, E. Colombo, R. Vinck, C. Mari, R. Rubbiani, M. Patra,* and G. Gasser,* ChemBioChem, 2020, 21, 2966-2973 (invited contribution for the issue on the 1st workshop on Metals in Medicine in Paris).
DOI: http://dx.doi.org/10.1002/cbic.202000289 - Synthesis, Characterization and Antiparasitic Activity of Organometallic Derivatives of the Anthelmintic Drug Albendazole
Y. Lin, Y.C. Ong, S. Keller, J. Karges, R. Bouchene, E. Manoury, O. Blacque, J. Müller, N. Anghel, A. Hemphill, C. Häberli, A.C. Taki, R.B. Gasser, K. Cariou,* J. Keiser,* and G. Gasser,* Dalton Trans., 2020, 49, 6616-6626.
DOI: http://dx.doi.org/10.1039/d0dt01107j - A Ruthenium(II) Complex Containing a Redox-Active Semiquinonate Ligand as Potential Chemotherapeutic Agent: From Synthesis to in vivo Studies
A. Notaro, A. Frei, R. Rubbiani, M. Jakubaszek, U. Basu, S. Koch, C. Mari, M. Dotou, O. Blacque, J. Gouyon, F. Bedioui, N. Rotthowe, R.F. Winter, B. Goud, S. Ferrari, M. Tharaud, M. Řezáčová, J. Humajová, P. Tomšík, and G. Gasser,* J. Med. Chem., 2020, 63, 5568–5584.
DOI: https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c00431 - Rationally Designed Long-Wavelength Absorbing Ru(II) Polypyridyl Complexes as Photosensitizers for Photodynamic Therapy
J. Karges, F. Heinemann, M. Jakubaszek, F. Maschietto, C. Subecz, M. Dotou, R. Vinck, O. Blacque, M. Tharaud, B. Goud, E. Viñuelas Zahínos, B. Spingler,* I. Ciofini,* and G. Gasser,* J. Am. Chem. Soc., 2020, 142, 6578-6587.
DOI: http://dx.doi.org/10.1021/jacs.9b13620 - Increasing the Cytotoxicity of Ru(II) Polypyridyl Complexes by tuning the Electronic Structure of Dioxo Ligands
A. Notaro, M. Jakubaszek, N. Rotthowe, F. Maschietto, R. Vinck, P.S. Felder, B. Goud, M. Tharaud, I. Ciofini, F. Bedioui, R.F. Winter, and G. Gasser,* J. Am. Chem. Soc., 2020, 142, 6066-6084.
DOI: http://dx.doi.org/10.1021/jacs.9b12464 - Novel Ruthenium(II) Polypyridyl Complexes with Flavonoid Ligands as Anticancer Drug Candidates
A.-C. Munteanu, A. Notaro, M. Jakubaszek, J. Cowell, M. Tharaud, B. Goud, V. Uivarosi, and G. Gasser, Inorg. Chem., 2020, 59, 4424-4434.
DOI: http://dx.doi.org/10.102/acs.inorgchem.9b03562 - A Maltol-containing Ruthenium Polypyridyl Complex as a Potential Anticancer Agent
A. Notaro, M. Jakubaszek, S. Koch, R. Rubbiani, O. Dömötör, E.A. Enyedy, M. Dotou, F. Bedioui, M. Tharaud, B. Goud, S. Ferrari, E. Alessio and G. Gasser,* Chem. Eur. J., 2020, 26, 4997–5009.
DOI: http://dx.doi.org/10.1002/chem.201904877 - A Multiaction and Multitarget Ru(II)-Pt(IV) Conjugate Combining Cancer Activated Chemotherapy and Photodynamic Therapy to Overcome Drug Resistant Cancers
J. Karges, T. Reddy, M. Tharaud, D. Gibson,* and G. Gasser,* Angew. Chem. Int. Ed., 2020, 59, 7069-7075.
DOI: http://dx.doi.org/10.1002/anie.201916400 - Ruthenium-Initiated Polymerization of Lactide: A Route to Remarkable Cellular Uptake for Photodynamic Therapy of Cancer
N. Soliman, L.K. McKenzie, J. Karges, E. Bertrand, M. Tharaud, M. Jakubaszek, V. Guérineau, B. Goud, M. Hollenstein, G. Gasser,* C.M. Thomas,* Chem. Sci., 2020, 11, 2657-2663.
DOI: http://dx.doi.org/10.1039/C9SC05976H - FeIII–salen based Probes for the Selective and Sensitive Detection of E450 in Foodstuff
P. Yadav, M. Jakubaszek, B. Spingler, B. Goud, G. Gasser, and F. Zelder,* Chem. Eur. J., 2020, 26, 5717-5723.
DOI: http://dx.doi.org/10.1002/chem.201905686/ - Note of Caution for the Aqueous Behaviour of Metal-based Drug Candidates
A. Notaro, G. Gasser,* and A. Castonguay,* ChemMedChem, 2020, 15, 345-348.
DOI: http://dx.doi.org/10.1002/cmdc.201900677 - Metal Dipyrrin Complexes as Potential Photosensitizers for Photodynamic Therapy
J. Karges, O. Blacque and G. Gasser,* Inorg. Chim. Acta, 2020, 505, 119482.
DOI: http://dx.doi.org/10.1016/j.ica.2020.119482 - Design of a Nanobody-containing Ru(II) Polypyridyl Conjugate as a Photosensitizer for Epidermal Growth Factor Receptor Targeted Photodynamic
J. Karges, M. Jakubaszek, C. Mari, K. Zarschler, B Goud, H. Stephan, and G. Gasser,* ChemBioChem, 2020, 21, 531-542 (invited contribution for the issue on the 1st workshop on Metals in Medicine in Paris).
DOI: http://dx.doi.org/10.1002/cbic.201900419 OPEN ACCESS - A Luminescent NOTA-based Terbium(III) ‘Turn-Off’ Sensor for Copper
M. Clerc, F. Heinemann, B. Spingler* and G. Gasser,* Inorg. Chem, 2020, 59, 669-677.
DOI: http://dx.doi.org/10.1021/acs.inorgchem.9b02934/ - Synthesis, Characterization, Kinetic Investigation and Biological Evaluation of Re(I) Di- and Tricarbonyl Complexes with Tertiary Phosphine Ligands
L. Gantsho, M. Dotou, M. Jakubaszek, B. Goud, G. Gasser, H.G. Visser,* and M. Schutte-Smith, Dalton Trans., 2020, 49, 35-46.
DOI: http://dx.doi.org/10.1039/C9DT04025K - Synthesis, Characterisation and Biological Evaluation of π-Extended Fe(II) Bipyridine Complexes
J. Karges and G. Gasser,* Inorg. Chim. Acta., 2020, 499, 119196 (invited contribution for the special issue in honour of Prof. Tara P. Dasgupta).
DOI: http://dx.doi.org/10.1016/j.ica.2019.119196
2019
- Targeted Photoredox Catalysis in Cancer Cells
H. Huang, S. Banerjee, K. Qiu, P. Zhang, O. Blacque, T. Malcomson, M.J. Paterson, G.J. Clarkson, M. Staniforth, V.G. Stavros, G. Gasser,* H. Chao,* and P.J. Sadler,* Nature. Chem., 2019, 11, 1041-1048.
DOI: http://dx.doi.org/10.1038/s41557-019-0328-4 - Polymeric Bis(dipyrrinato) Zinc(II) Nanoparticles as Selective Imaging Probes for Lysosomes of Cancer Cells
J. Karges, O. Blacque, H. Chao,* and G. Gasser,* Inorg. Chem., 2019, 58, 12422-12432.
DOI: http://dx.doi.org/10.102/acs.inorgchem.9b02019 - Polymeric Encapsulation of Novel Homoleptic Bis(dipyrrinato) Zinc(II) Complexes with Long Lifetimes for Applications as Photodynamic Therapy Photosensitisers
J. Karges, U. Basu, O. Blacque, H. Chao,* and G. Gasser,* Angew. Chem. Int. Ed, 2019, 58, 14334-14340.
DOI: http://dx.doi.org/10.1002/anie.201907856 - Towards Long Wavelength Absorbing Photodynamic Therapy Photosensitizers via the Extension of a [Ru(bipy)3]2+ Core
J. Karges, O. Blacque, P. Goldner, H. Chao and G. Gasser,* Eur. J. Inorg. Chem., 2019, 32, 3704-3712.
DOI: http://dx.doi.org/10.1002/ejic.201900569 - Systematic Investigation of the Potential Antiproliferative Activity of a Series of Ruthenium Terpyridine Complexes (II) Polypyridyl Complexes as Photosensitisers for Photodynamic Therapy
J. Karges, O. Blacque, M. Jakubaszek, B. Goud, P. Goldner and G. Gasser,* J. Inorg. Biochem., 2019, 198, 110752 (invited contribution for the virtual issue on the 9th Asian Bioinorganic Chemistry Conference (AsBIC-9) in Singapore).
DOI: http://dx.doi.org/10.1016/j.jinorgbio.2019.110752 - Evaluation of the Potential of Cobalamin Derivatives Bearing Ru(II) Polypyridyl Complexes as Photosensitisers for Photodynamic Therapy
M. Jakubaszek, J. Rossier, J. Karges, J. Delasoie, B. Goud, G. Gasser* and F. Zobi,* Helv. Chim. Acta, 2019, 102, e1900104.
DOI: http://dx.doi.org/10.1002/hlca.201900104 - Towards Light Activated Ruthenium-Arene (RAPTA-type) Prodrug Drug Candidates
A.K. Renfrew, J. Karges, R. Scopelliti, F.D. Bobbink, P. Nowak-Sliwinska, G. Gasser,* and P.J. Dyson,* ChemBioChem, 2019, 20, 2876-2882 (invited contribution for the issue on the 1st workshop on Metals in Medicine in Paris).
DOI: http://dx.doi.org/10.1002/cbic.201900236
VIP Article
Highlighted in ChemistryViews - A Ru(II) Polypyridyl Complex Bearing Aldehyde Functions as a Versatile Synthetic Precursor for Long-Wavelength Absorbing Photodynamic Therapy Photosensitizers
J. Karges, F. Heinemann, F. Maschietto, M. Patra, O. Blacque, I. Ciofini, B. Spingler,* and G. Gasser,* Bioorg. Med. Chem., 2019, 12, 2666-2675 (invited article for the special issue “from controlling chemical bonding to deciphering and manipulating biological processes”).
DOI: http://dx.doi.org/10.1016/j.bmc.2019.05.011 - Investigation of Photo-Activation on Ruthenium(II)-arene Complexes for the Discovery of Potential Selective Cytotoxic Complexes
U. Basu, J. Karges, F. Chotard, C. Balan, P. Le Gendre, G. Gasser,* E. Bodio,* R. Malacea Kabbara,* Polyhedron, 2019, 172, 22-27 (invited article on the occasion of the 65th birthday of Prof. Akhil R.Chakravarty).
DOI: http://dx.doi.org/10.1016/j.poly.2019.02.041 - Targeting of the Mitochondrium by Dinuclear Thiolato-bridged Arene Ruthenium Complexes in Cancer Cells and in the Apicomplexan Parasite Neospora caninum
A.P. Basto, N. Anghel, R. Rubbiani, J. Müller, D. Stibal, F. Giannini, G. Süss-Fink, V. Balmer, G. Gasser,* J. Furrer,* and A. Hemphill,* Metallomics, 2019, 11, 462-464.
DOI: http://dx.doi.org/10.1039/C8MT00307F OPEN ACCESS - Synthesis, Characterisation and Biological Evaluation of Red-Absorbing Fe(II) Polypyridine Complexes
J. Karges, P. Goldner and G. Gasser,* Inorganics, 2019, 7, 4.
DOI: http://dx.doi.org/10.3390/inorganics7010004 OPEN ACCESS - Mesoporous Silica Nanoparticles Functionalised with a Photoactive Ruthenium(II) Complex: Exploring the Formulation of a Metal-based Photodynamic Therapy Photosensitiser
Y. Ellahioui, M. Patra, C. Mari, R. Kaabi, J. Karges, G. Gasser* and S, Gómez-Ruiz,* Dalton Trans., 2019, 48, 5940-5951(invited article for the themed issue Bioinspired Reactivity and Coordination Chemistry).
DOI: http://dx.doi.org/10.1039/C8DT02392A - Biological Evaluation of the NIR-Emissive Ruby Analogue [Cr(ddpd)2]3+ as a Photodynamic Therapy Photosensitisers
U. Basu, S. Otto, K. Heinze,* and G. Gasser,* Eur. J. Inorg. Chem., 2019, 1, 37-41.
DOI: http://dx.doi.org/10.1002/ejic.201801023
2018
- Assessment of Tegumental Damage to S. mansoni and S. haematobium after in vitro Exposure to Ferrocenyl, Ruthenocenyl and Benzyl Derivatives of Oxamniquine using Scanning Electron Microscopy
V. Buchter, J. Hess, G. Gasser, and J. Keiser,* Parasites & Vectors, 2018, 11, 580.
DOI: http://dx.doi.org/10.1186/s13071-018-3132-x OPEN ACCESS - Linker Chemistry Dictates the Delivery of Phototoxic Organometallic Rhenium(I) Complex to Human Cervical Cancer Cells from Core Crosslinked Star Polymer Nanoparticles
S. Hwa Yu, M. Patra, S. Ferrari, P. Ramirez Garcia, N. Veldhuis, B. Graham, J.F. Quinn, M.R. Whittaker,* G. Gasser,* and T.P. Davis,* J. Mat. Chem. B., 2018, 6, 7805-7810.
DOI: http://dx.doi.org/10.1039/C8TB02464B - Synthesis, Characterization and Biological Activity of Organometallic Derivatives of the Antimalarial Drug Mefloquine as New Antischistosomal Drug Candidates
F. d’Orchymont, J. Hess, G. Panic, M. Jakubaszek, J. Keiser,* and G. Gasser,* Med. Chem. Commun., 2018, 9, 1905-1909.
DOI: http://dx.doi.org/10.1039/C8MD00396C - ATR-mediated global fork slowing and reversal assist fork traverse and prevent chromosomal breakage at interstrand DNA crosslinks
K. Mutrej, J. Krietsch, J. Hess, S. Ursich, M. Berti, R. Zellweger, M. Patra, G. Gasser and M. Lopes,* Cell Reports, 2018, 24, 2629-2642.
DOI: http://dx.doi.org/10.1016/j.celrep.2018.08.019 OPEN ACCESS - A potent, selective and orally bioavailable inhibitor of the protein tyrosine phosphatase PTP1B improves insulin and leptin signaling in animal models
NN. Krishnan, K.F. Konidaris, G. Gasser, N.K. Tonks,* J. Biol. Chem., 2018, 293, 1517-1525.
DOI: http://dx.doi.org/10.1074/jbc.C117.819110
2017
- A solid phase-assisted approach for the facile synthesis of a highly water-soluble zirconium-89 chelator for radiopharmaceutical development
M. Briand, M.L. Aulsebrook, T.L. Mindt* and G. Gasser,* Dalton Trans., 2017, 46, 16387-16389.
DOI: http://dx.doi.org/10.1039/C7DT03639F - Novel Organometallic Oxamniquine Derivatives with Cross-species Activity against Schistosoma mansoni and S. haematobium
J. Hess, G. Panic, M. Patra, L. Mastrobuoni, O. Blacque, S. Roy, J. Keiser* and G. Gasser,* ACS Infect. Dis., 2017, 3, 645-652.
DOI: http://dx.doi.org/10.1021/acsinfecdis.7b00054 - Extending the Excitation Wavelength of Potential Photosensitizers via Appendage of a Kinetically-Stable Terbium(III) Macrocyclic Complex for Applications in Photodynamic Therapy
P. Ung,* M. Clerc, H. Huang, H. Chao, M. Seitz, B. Boyd, B. Graham and G. Gasser,* Inorg. Chem., 2017, 56, 7960-7974.
DOI: http://dx.doi.org/10.1021/acs.inorgchem.7b00677 - Dinuclear Thiophenolato-Bridged Arene Ruthenium Complexes as Promising Antiparasitic Agents
A.P. Basto, J. Müller, R. Rubbiani, F. Giannini, G. Süss-Fink, V. Balmer, A. Hemphill,* G. Gasser* and J. Furrer,* Antimicrob. Agents Chemother., 2017, 61, e01031-17.
DOI: http://dx.doi.org/10.1128/AAC.01031-17 OPEN ACCESS - Evaluation of the Medicinal Potential of Two Ruthenium(II) Polypyridine Complexes as One- and Two-Photon Photodynamic Therapy Photosensitizers
J. Hess, H. Huang, A. Kaiser, V. Pierroz, O. Blacque, H. Chao,* G. Gasser,* Chem. Eur. J., 2017, 23, 9888-9896.
DOI: http://dx.doi.org/10.1002/chem.201701392
VIP Article
Highlighted in ChemistryViews - Immobilisation of multiple ligands using peptide nucleic acids: a strategy to prepare the microenvironment for cell culture
E.-J. Lee, C. Mari, M. Gel, J. Gardiner, G. Gasser and D. Haylock,* ChemistySelect, 2017, 2, 4028-4032.
DOI: http://dx.doi.org/10.1002/slct.201700541 - Combining Imaging and Anticancer Properties with Heterobimetallic Pt(II)/M(I) (M = Re, 99mTc) Complexes
L. Quental, P. Raposinho, F. Mendes, I. Santos, C. Navarro-Ranninger, A. Alvarez-Valdes, H. Huang, H. Chao, R. Rubbiani, G. Gasser,* A.G. Quiroga* and A. Paulo,* Dalton Trans., 2017, 46, 14523-14536 (invited contribution for the special issue “Frontiers in Radionuclide Imaging and Therapy” dedicated to Prof. Isabel Santos).
DOI: http://dx.doi.org/10.1039/C7DT00043J - Multi-Stimuli Responsive Block Copolymers as Smart Release Platform for a Polypyridyl Ruthenium Complexes
M. Appold, C. Mari, C. Lederle, J. Elbert, C. Schmidt, I. Ott, B. Stühn, G. Gasser,* and M. Gallei,* Polym. Chem., 2017, 8, 890-900.
DOI: http://dx.doi.org/10.1039/c6py02026g OPEN ACCESS - Towards the Synthesis of New Tumor Targeting Photosensitizers for Photodynamic Therapy and Imagining Applications
G. Mion, C. Mari, T. Da Ros, R. Rubbiani, G. Gasser,* and T. Gianferrara,* ChemistrySelect, 2017, 2, 190-200.
DOI: http://dx.doi.org/10.1002/slct.201601960 - Influence of the Dissolution Solvent on the Cytotoxicity of Octahedral Cationic Ir(III) Hydride Complexes
H. Huang, N. Humbert, V. Bizet, H. Chao,* C. Mazet,* and G. Gasser,* J. Organomet. Chem., 2017, 839, 15-18 (invited contribution for the special issue on the 8th International Symposium on Bioorganometallic Chemistry).
DOI: http://dx.doi.org/10.1016/j.jorganchem.2016.12.010 - Comparison of the octadentate bifunctional chelator DFO*-pPhe-NCS and the clinically used hexadentate bifunctional chelator DFO-pPhe-NCS for ⁸⁹Zr-immuno-PET
D.J. Vugts,* C. Klaver, C. Sewing, A.J. Poot, K. Adamzek, S. Huegli, C. Mari. H. G.W.M. Visser, I.E. Valverde, G. Gasser,* T.L. Mindt,* and G.A.M.S. van Dongen, Eur. J. Nucl. Med. Mol. Imag., 2017, 44, 286-295.
DOI: http://dx.doi.org/10.1007/s00259-016-3499-x OPEN ACCESS
EJNMMI Best Article Award 2019 - Evaluation of Perylene Bisimide-based RuII and IrIII Complexes as Photosensitizers for Photodynamic Therapy
C. Mari, H. Huang, R. Rubbiani, M. Schulze, F. Würthner, H. Chao,* and G. Gasser,* Eur. J. Inorg. Chem., 2017, 12, 1745-1752 (invited contribution for the special issue on Metal Anticancer Complexes – Activity, Mechanism of Action and Future perspective).
DOI: http://dx.doi.org/10.1002/ejic.201600516
Most-accessed original research article from 2017 - Biological Evaluation of Nitrile Containing Ru(II) Polypyridyl Complexes as Potential Photodynamic Therapy Agents
C. Mari, R. Rubbiani and G. Gasser,* Inorg. Chim. Acta, 2017, 454C, 21-26 (invited article for the special issue in memory of the late Prof. Karen J. Brewer).
DOI: http://dx.doi.org/10.1016/j.ica.2015.10.010
2016
- Assessment of the Nematocidal Activity of Metallocenyl Analogues of Monepantel
J. Hess, M. Patra, A. Jabbar, V. Pierroz, S. Konatschnig, B. Spingler, S. Ferrari, R.B. Gasser* and G. Gasser* Dalton Trans., 2016, 45, 17662-17671.
DOI: http://dx.doi.org/10.1039/C6DT03376H OPEN ACCESS - Synthesis, Characterization and Biological Activity of Ferrocenyl Analogues of the Anthelmintic Drug Monepantel
J. Hess, M. Patra, V. Pierroz, B. Spingler, A. Jabbar, S. Ferrari, R.B. Gasser* and G. Gasser* Organometallics, 2016, 35, 3369–3377.
DOI: http://dx.doi.org/10.1021/acs.organomet.6b00577 - Organometallic Derivatisation of the Nematocidal Drug Monepantel leads to Promising Antiparisitic Drug Candidates
J. Hess, M. Patra, L. Rangasamy, S. Konatschnig, O. Blacque, A. Jabbar, P. Mac, E.M. Jorgensen, R.B.Gasser,* and G. Gasser, * Chem. Eur. J., 2016, 22, 16602-16612.
DOI: http://dx.doi.org/10.1002/chem.201602851 - N-Heterocyclic Carbene-Polyethyleneimine (PEI) Platinum Complexes show in vitro and in vivo Antitumor Efficacy
N. Chekkat, G. Dahm, E. Chardon, M. Wantz, J. Sitz, M. Decossas, O. Lambert, B. Frisch, R. Rubbiani, G. Gasser, G. Guichard, S. Fournel,* and S. Bellemin-Laponnaz,* Bioconjugate Chem., 2016, 27, 1942-1948.
DOI: http://dx.doi.org/10.1021/acs.bioconjchem.6b00320 - Dual Mode of Cell Death upon the Photo-Irradiation of a RuII Polypyridyl Complex in Interphase or Mitosis
V. Pierroz, R. Rubbiani, C. Gentili, M. Patra, C. Mari, G. Gasser,* and S. Ferrari,* Chem. Sci., 2016, 7, 6115-6124.
DOI: http://dx.doi.org/10.1039/C6SC00387G - Towards 99mTc-based Imaging Agents with Effective Doxorubicin Mimetics: A Molecular and Cellular Study
S. Imstepf, V. Pierroz, P. Raposinho, M. Felber, T. Fox, C. Fernandes, G. Gasser, I.R. Santos, and R. Alberto,* Dalton Trans., 2016, 45, 13025-13033.
DOI: http://dx.doi.org/10.1039/C6DT00871B - A Disassembly Strategy for Imaging Endogenous Pyrophosphate in Mitochondria using a FeIII-salen Complex
N. Kumari, H. Huang, H. Chao, G. Gasser, and F. Zelder, ChemBioChem, 2016, 17, 1211-1215.
DOI: http://dx.doi.org/10.1002/cbic.201600195 - Selective Photorelease of an Organometallic-Containing Enzyme Inhibitor
A. Leonidova, C. Mari, C. Aebersold, and G. Gasser,* Organometallics, 2016, 5, 851-854.
DOI: http://dx.doi.org/10.1021/acs.organomet.6b00029 - Sedaxicenes: potential new antifungal Ferrocene-based Agents?
R. Rubbiani,* O. Blacque, and G. Gasser,* Dalton Trans., 2016, 45, 6619-6626.
DOI: http://dx.doi.org/10.1039/C5DT04231C OPEN ACCESS - Bimodal X-ray and Infrared Imaging of an Organometallic Derivatives of Praziquantel in Schistosoma mansoni
S. Clède, N. Cowan, F. Lambert, H.C. Bertrand, R. Rubbiani, M. Patra, J. Hess, C. Sandt, N. Trcera, G. Gasser,* J. Keiser,* and C. Policar,* ChemBioChem, 2016, 17, 1004-1007.
DOI: http://dx.doi.org/10.1002/cbic.201500688 - Cellular Uptake and Photo-Cytotoxicity of a Gadolinium(III)-DOTA-Naphtalimide Complex “Clicked” to a lipidated Tat Peptide
W.I. O’Malley, R. Rubbiani, M.L. Ausebrook, M.R. Grace, L. Spiccia, K.L. Tuck,* G. Gasser,* and B. Graham,* Molecules, 2016, 21, 194 (invited contribution for the special issue on photoresponsive drugs).
DOI: http://dx.doi.org/10.3390/molecules21020194 OPEN ACCESS - Luminescent Alkyne-bearing Terbium(III) Complexes and their Application to Bioorthogonal Protein Labeling
W.I. O’Malley, E.H. Abdelkader, M.L. Ausebrook, R. Rubbiani, C.-T. Loh, M.R. Grace, L. Spiccia, G. Gasser, G. Otting, K.L. Tuck,* and B. Graham,* Inorg. Chem., 2016, 55, 1674-1682.
DOI: http://dx.doi.org/10.1021/acs.inorgchem.5b02605 - Organometallic Rhenium Complexes Divert Doxorubicin to the Mitochondria
S. Imstepf, V. Pierroz, R. Rubbiani, M. Felber, T. Fox, G. Gasser and R. Alberto,* Angew. Chem. Int. Ed., 2016, 55, 2792-2795.
DOI: http://dx.doi.org/10.1002/anie.20151143 - Synthesis, Characterization and Biological Evaluation of novel Ru(II)-Arene Complexes containing Intercalating Ligands
S. Nikolic, L. Rangasamy, N. Gligorijevic, S. Arandelovic, S. Radulovic, G. Gasser* and S. Grguric-Sipka,* J. Inorg. Biochem., 2016, 160, 156-165 (invited contribution for the special issue for the COST Action CM1105).
DOI: http://dx.doi.org/10.1016/j.jinorgbio.2016.01.005
- Insertion of Organometallic Moieties into Peptides and Peptide Nucleic Acids using Alternative “Click” Strategies
C. Mari, S. Mosberger, N. Llorente, S. Spreckelmeyer and G. Gasser,* Inorg. Chem. Frontiers, 2016, 3, 397-405 (invited contribution for the themed issue “Emerging Investigators”).
DOI: http://dx.doi.org/10.1039/C5QI00270B OPEN ACCESS - A Photocaged Inositol-Pyrophosphate: Synthesis, Cellular Delivery, Photochemical Release, and its Effect on PH-Domain Translocation
I. Pavlovic, D.T. Thakor, J.R. Vargas, C.J. McKinlay, S. Haucke, P. Anstaett, R.C. Camuna, G. Gasser, C. Schlutz, P.A. Wender,* and H.J. Jessen, Nature Commun., 2016, 7, DOI: 10.1038/ncomms10622.
DOI: http://dx.doi.org/10.1038/ncomms10622 OPEN ACCESS
2015
- Nuclear Targeting with an Auger Electron Emitter Potentiates the Action of a Widely-Used Antineoplastic Drug
S. Imstepf, V. Pierroz, P. Raposinho, M. Bauwens, M. Felber, T. Fox, A. Shapiro, R. Freudenberg, C. Fernandes, S. Gama, G. Gasser, F. Motthagy, I. Santos, R. Alberto,* Bioconjugate Chem., 2015, 26, 2397-2407.
DOI: http://dx.doi.org/10.1021/acs.bioconjchem.5b00466 - Induction of Cytotoxicity through Photo-release of Aminoferrocene
A. Leonidova, P. Anstaett, V. Pierroz, C. Mari, B. Spingler, S. Ferrari and G. Gasser,* Inorg. Chem., 2015, 54, 9740-9748.
DOI: http://dx.doi.org/10.1021/acs.inorgchem.5b01332 - Highly Charged Ruthenium(II) Polypyridyl Complexes as Lysosome-Localized Photosensitizers for Two-Photon Photodynamic Therapy
H. Huang, B. Yu, P. Zhang, J. Huang, Y. Chen, G. Gasser,* L. Ji and H. Chao,* Angew. Chem. Int. Ed., 2015, 54, 14049-14052.
DOI: http://dx.doi.org/10.1002/anie.201507800
VIP Article - Two-Photon Uncageable Enzyme Inhibitors bearing Targeting Vectors
P. Anstaett, V. Pierroz, S. Ferrari, G. Gasser,* Photochem. Photobiol. Sci., 2015, 14, 1821-1825.
DOI: http://dx.doi.org/10.1039/C5PP00245A OPEN ACCESS - Phototoxic Activity and DNA Interactions of New Water Soluble Porphyrin and their Re(I) Conjugates
G. Mion, T. Gianferrara,* A. Bergamo, G. Gasser,* V. Pierroz, R. Rubbiani, R. Vilar,* A. Leczkowska and E. Alessio, ChemMedChem, 2015, 10, 1901-1914.
DOI: http://dx.doi.org/10.1002/cmdc.201500288 - In vivo Demonstration of a Tumour Pretargeting Approach with Peptide Nucleic Acids as Complementary System
A. Leonidova, C. Foerster, K. Zarschler, M. Schubert, H.-J. Pietzsch, J. Steinback, R. Bergmann, N. Metzler-Nolte, H. Stephan, G. Gasser,* Chem. Sci., 2015, 6, 5601-5616. Highlighted on chemie.de, bionity.com, ChemieXtra and Helmholtz Association.
DOI: http://dx.doi.org/10.1039/C5SC00951K OPEN ACCESS - Unexpected High Photothermal Conversion Efficiency of Gold Nanospheres upon Grafting with Two-Photon Luminescent Ruthenium(II) Complexes: A Way Towards Cancer Therapy?
P. Zhang, J. Wang, H. Huang, B. Yu, K. Qiu, J. Huang, S. Wang, L. Jiang, G. Gasser, L. Ji and H. Chao,* Biomaterials, 2015, 63, 102-114.
DOI: http://dx.doi.org/10.1016/j.biomaterials.2015.06.012 - Direct Imaging of Biological Sulfur Dioxide Derivatives in Vivo Using a Two-Photon Phosphorescent Probe
G. Li, Y. Chen, J. Wang, J. Wu, G. Gasser, L. Ji and H. Chao,* Biomaterials, 2015, 63, 128-136.
DOI: http://dx.doi.org/10.1016/j.biomaterials.2015.06.014 - Towards Selective Light-Activated Ru(II)-Based Prodrug Candidates
C. Mari, V. Pierroz, A. Leonidova, S. Ferrari, and G. Gasser,* Eur. J. Inorg. Chem., 2015, 13, 3879-3891.
DOI: http://dx.doi.org/10.1002/ejic.201500602 - Reply to Commentary by Trentham et al. on “Caged Phosphate and the Slips and Misses in Determination of Quantum Yields for Ultraviolet-A-Induced Photouncaging” by Gasser et al.
P. Anstaett,* A. Leonidova, E. Janett, C. Bochet* and G. Gasser,* ChemPhysChem, 2015, 16, 1863-1866.
DOI: http://dx.doi.org/10.1002/cphc.201500178 - Caged Phosphate and the Slips and Misses in Determination of Quantum Yields for UV-A Photouncaging
P. Anstaett, A. Leonidova and G. Gasser* ChemPhysChem, 2015, 16, 1857-1860.
DOI: http://dx.doi.org/10.1002/cphc.201402547 - Internal Labeling Strategy of Large RNAs with Minimal Perturbation Using Fluorescent PNA
A. Schmitz, S. Zelger-Paulus, G. Gasser,* and R.K.O. Sigel,* ChemBioChem, 2015, 16, 1302-1306.
DOI: http://dx.doi.org/10.1002/cbic.201500180 - (Metallo)porphyrins as Potent Phototoxic Anticancer Agents After Irradiation with Red Light
P.M. Antoni, A. Naik, I. Albert, R. Rubbiani, S. Gupta, P. Ruiz-Sánchez, P. Munikorn, J. M. Mateos, V. Luginbuehl, P. Thamyongkit, U. Ziegler, G. Gasser, G. Jeschke and B. Spingler,* Chem. Eur. J., 2015, 21, 1179-1183.
DOI: http://dx.doi.org/10.1002/chem.201405470 - An Organometallic Structure-Activity Relationship Study Reveals the Essential Role of a Re(CO)3 Moiety in the Activity Against Gram-Positive Pathogens Including MRSA
M. Patra, M. Wenzel, P. Prochnow, V. Pierroz, G. Gasser, J.E. Bandow and N. Metzler-Nolte,* Chem. Sci., 2015, 6, 214-224.
DOI: http://dx.doi.org/10.1039/C4SC02709D OPEN ACCESS
2014
- Anticancer Profile of a Series of Gold(III) (2-phenyl)pyridine Complexes
R. Rubbiani,* T.N. Zehnder, C. Mari, O. Blacque, K. Venkatesan,* and G. Gasser,* ChemMedChem, 2014, 9, 2781-2790.
DOI: http://dx.doi.org.10.1002/cmdc.201402446 - Enantioselective Total Syntheses of the Proposed Structures of Prevezol B and Evaluation of Anti-Cancer Activity
A.E. Leung, R. Rubbiani, G. Gasser, and K.L. Tuck,* Org. Biomol. Chem., 2014, 12, 8239–8246.
DOI: http://dx.doi.org/10.1039/C4OB01662A - Synthesis, Characterization and Biological Evaluation of New Ru(II) Polypyridyl Photosensitizers for Photodynamic Therapy
A. Frei, R. Rubbiani, S. Tubafard, O. Blacque, P. Anstaett, A. Felgentraeger, T. Maisch, L. Spiccia and G. Gasser,* J. Med. Chem., 2014, 57, 7280-7292.
DOI: http://dx.doi.org.10.1021/jm500566f
Highly cited article in J. Med. Chem. of the year 2014. - In vitro and in vivo Antischistosomal Activity of Ferroquine Derivative
J. Keiser,* M. Vargas, R. Rubbiani, G. Gasser, and C. Biot, Parasites & Vectors, 2014, 7, 424.
DOI: http://dx.doi.org.10.1186/1756-3305-7-424 OPEN ACCESS - An Octadentate Bifunctional Chelating Agent for the Development of Stable Zirconium-89 Based Molecular Imaging Probes
M. Patra, A. Baumann, C. Mari, C.A. Fischer, O. Blacque, D. Häussinger, G. Gasser* and T.L. Mindt,* Chem. Commun., 2014, 50, 11523-11525.
DOI: http://dx.doi.org/10.1039/C4CC05558F - Activity of Praziquantel Enantiomers and Main Metabolites against Schistosoma mansoni
I. Meister, K. Ingram-Sieber, N. Cowan, M.H. Todd, M.N. Robertson, C. Meli, M. Patra, G. Gasser and J. Keiser* Antimicrob. Agents Chemother., 2014, 58, 5466-5472.
DOI: http://dx.doi.org/10.1128/AAC.02741-14 - DNA Intercalating Ru(II) Polypyridyl Complexes as effective Photosensitizers in Photodynamic Therapy
C. Mari, V. Pierroz, R. Rubbiani, M. Patra, J. Hess, B. Spingler, J. Schur, L. Oehninger, I. Ott, L. Salassa, S. Ferrari, and G. Gasser,* Chem. Eur. J., 2014, 44, 14421-14436.
DOI: http://dx.doi.org/10.1002/chem.201402796 - Photo-Induced Uncaging of a Specific Re(I) Organometallic Complex in Living Cells
A. Leonidova, V. Pierroz, R. Rubbiani, Y. Lan. A.G. Schmitz, A. Kaech, R.K.O. Sigel, S. Ferrari, and G. Gasser,* Chem. Sci., 2014, 5, 4044 – 4056.
DOI: http://dx.doi.org/10.1039/C3SC53550A OPEN ACCESS - Enhanced Cytotoxicity through Conjugation of a “Clickable” Luminescent Re(I) Complex to a Cell-penetrating Lipopeptide
A. Leonidova, V. Pierroz, L.A. Adams, N. Barlow, S. Ferrari, B. Graham,* and G. Gasser,* ACS Med. Chem. Lett., 2014, 5, 809-814.
DOI: http://dx.doi.org/10.1021/ml500158 - Visible Light-Induced Annhihilation of Tumour Cells Using Novel Platinum-Porphyrin Conjugates
A. Naik, R. Rubbiani, G. Gasser, B. Spingler,* Angew. Chem. Int. Ed., 2014, 53, 6938-6941.
DOI: http://dx.doi.org/10.1002.anie.201400533 - A Novel, Mercury-Free Synthetic Pathway for Trifluoromethylthio-Subsituted Metallocenes
J. Hess, S. Konatschnig, S. Morard, V. Pierroz, S. Ferrari, B. Spingler and G. Gasser,* Inorg. Chem., 2014, 53, 3662-3667.
DOI: http://dx.doi.org/10.1021/ic403169z - Bis(dipyridophenazine)(2-(2′-pyridyl)pyrimidine-4-carboxylic acid)ruthenium(II) hexafluorophosphate: A Lesson to Stubborness
T. Joshi,* V. Pierroz, S. Ferrari and G. Gasser,* ChemMedChem, 2014, 9, 1419-1427.
DOI: http://dx.doi.org/10.1002/cmdc.201400029
One of the top 10 most cited articles published by ChemMedChem in 2014. - Towards matched Pairs of Porphyrin-Re(I)/99mTc(I) Conjugates that combine Photodynamic Activity with Fluorescence- and Radio-Imaging
T. Gianferrara,* C. Spagnul, R. Alberto,* G. Gasser, S. Ferrari, V. Pierroz, A. Bergamo, E. Alessio,* ChemMedChem, 2014, 9, 1231-1237.
DOI: http://dx.doi.org/10.1002/cmdc.201300501
One of the top 10 most cited articles published by ChemMedChem in 2014. - A Bis(dipyridophenazine)(2-(2′-pyridyl)pyrimidine-4-carboxylic acid) Ruthenium(II) Complex with Anticancer Action upon Photodeprotection
T. Joshi,* V. Pierroz, C. Mari, L. Gemperle, S. Ferrari and G. Gasser,* Angew. Chem. Int. Ed., 2014, 53, 2960-2963. Highlighted in Chimia.
DOI: http://dx.doi.org/10.1002/anie.201309576 - A Deadly Organometallic Luminescent Probe: Anticancer Activity of a Re(I) Bisquinoline Complex
I. Kitanovic, S. Can, H. Alborzina, A. Kitanovic, V. Pierroz, A. Leonidvoa, A. Pinto, B. Spingler, S. Ferrari, R. Molteni, A. Steffen,*, N. Metzler-Nolte,* S. Wölfl* and G. Gasser,* Chem. Eur. J., 2014, 20, 2496-2507. Highlighted in ChemistryViews.
DOI: http://dx.doi.org/10.1002/chem.20130401 - Towards Cancer-Cell Specific Phototoxic Organometallic Rhenium(I) complexes
A. Leonidova, V. Pierroz, R. Rubbiani, J. Heier, S. Ferrari, and G. Gasser,* Dalton Trans., 2014, 43, 4287-4294 (invited contribution to the themed issue “New Talent: Europe”).
DOI: http://dx.doi.org/10.1039/C3DT51817E OPEN ACCESS
2013
- In Vitro Metabolic Profile and In Vivo Antischistosomal Activity Studies of (η-Praziquantel)Cr(CO)3 Derivatives
M. Patra, K. Ingram, A. Leonidova, V. Pierroz, S. Ferrari, M.N. Robertson, M.H. Todd, J. Keiser* and G. Gasser,* J. Med. Chem., 2013, 56, 9192-9198.
DOI: http://dx.doi.org/10.1021/jm401287m - DMSO-mediated Ligand Dissociation: Renaissance for Biological Activity of N-heterocyclic-[Ru(η6-arene)Cl2] Drug Candidates
M. Patra,* T. Joshi, V. Pierroz, K. Ingram, M. Kaiser, S. Ferrari, B. Spingler, J. Keiser and G. Gasser,* Chem. Eur. J., 2013, 19, 14768-14772.
DOI: http://dx.doi.org/10.1002/chem.201303341 - Synthesis of Ferrocenyl and Ruthenocenyl Thioamide Derivatives Using a Single-Step Three-Component Reaction
M. Patra,* J. Hess, S. Konatschnig, B. Spingler and G. Gasser,* Organometallics, 2013, 32, 6098–6105.
DOI: http://dx.doi.org/10.1021/om400715 - An Environmentally Benign and Cost-Effective Synthesis of Aminoferrocene and Aminoruthenocene
A. Leonidova, T. Joshi, D. Nipkow, A. Frei, J.-E. Penner, S. Konatschnig, M. Patra and G. Gasser,* Organometallics, 2013, 32, 2037-204
DOI: http://dx.doi.org/10.1021/om400009g - Di-Heterometalation of Thiol-Functionalized Peptide Nucleic Acids
T. Joshi, M. Patra, L. Spiccia, and G. Gasser,* Artifical DNA: PNA & XNA, 2013, 4, 11-18 (invited contribution).
DOI: http://dx.doi.org/10.416/adna.24019 - Synthesis of Stable Peptide Nucleic Acid-Modified Gold Nanoparticles and their Assembly onto Gold Surfaces
P. Anstaett, Y. Zheng, T. Thai, A.M. Funston, U. Bach* and G. Gasser,* Angew. Chem. Int. Ed., 2013, 52, 4217–4220.
DOI: http://dx.doi.org/10.1002/anie.210209684 - Novel Water-Soluble 99mTc(I)/Re(I)-Porphyrin Conjugates as Potential Multimodal Agents for Molecular Imaging
C. Spagnul, R. Alberto,* G. Gasser, S. Ferrari, V. Pierroz, A. Bergamo, T. Gianferrara* and E. Alessio, J. Inorg. Biochem., 2013, 122, 57-65.
DOI: http://dx.doi.org/10.1016/j.jinorgbio.2012.12.016 - (η6-Praziquantel)Cr(CO)3 Derivatives with Remarkable In Vitro Anti-schistosomal Activity
M. Patra, K. Ingram, V. Pierroz, S. Ferrari, B. Spingler, R.B. Gasser, J. Keiser* and G. Gasser,* Chem. Eur. J., 2013, 19, 2232-2235.
DOI: http://dx.doi.org/10.1002/chem.20120429
2012
- Molecular and Cellular Characterization of the Biological Effects of Ruthenium(II) Complexes Incorporating 2-Pyridyl-2-Pyrimidine-4-Carboxylic Acid
V. Pierroz, T. Joshi, A. Leonidova, C. Mari, J. Schür, I. Ott, L. Spiccia,* S. Ferrari,* and G. Gasser,* J. Am. Chem. Soc., 2012, 134, 20376-20387.
Highlighted in Chimia and Chemistry in Australia.
DOI: http://dx.doi.org/10.1021/ja307288s - Ferrocenyl Derivatives of the Anthelminc Praziquantel: Design, Synthesis and Biological Evaluation
M. Patra, K. Ingram, V. Pierroz, S. Ferrari, B. Spingler, J. Keiser and G. Gasser,* J. Med. Chem., 2012, 55, 8790-8798.
DOI: http://dx.doi.org/10.1021/jm301077 - Electrochemical, Spectroscopic, Magnetic and Structural Studies of Complexes bearing Ferrocenyl Ligands of N-(3-hydroxypicolinoyl)picolinamide
G. Gasser,* C. Mari, M. Burkhart, S.J. Green,* J. Ribas, H. Stoeckli-Evans* and J.H.R. Tucker,* New. J. Chem., 2012, 36, 1819-1827.
DOI: http://dx.doi.org/10.1039/C2NJ40177K - Specific Uptake and Interactions of Peptide Nucleic Acid Derivatives with Biomimetic Membranes
T. Joshi, G. Gasser,* L.M. Martin* and L. Spiccia,* RSC Adv., 2012, 2, 4703-4712.
DOI: http://dx.doi.org/10.1039/C2RA20462B - Electrochemiluminescent Monomers for Solid Support Synthesis of Ru(II)-PNA Bioconjugates – Multimodal Biosensing Tools with Enhanced Duplex Stability
T. Joshi, G.J. Barbante, P.S. Francis, C.F. Hogan, A.M. Bond, G. Gasser* and L. Spiccia,* Inorg. Chem., 2012, 51, 3302-3315.
DOI: http://dx.doi.org/10.1021/ic202761w - Synthesis, Characterisation and Bioimaging of a New Fluorescent Rhenium-Containing PNA Bioconjugate
G. Gasser,* A. Pinto, S. Neumann, A.M. Sosniak, M. Seitz, K. Merz, R. Heumann and N. Metzler-Nolte,* Dalton Trans., 2012, 41, 2304-2313.
DOI: http://dx.doi.org/10.1039/C2DT12114J - Sandwich and Half-Sandwich Derivatives of Platensimycin: Synthesis and Biological Evaluation
M. Patra, G. Gasser, M. Wenzel, K. Merz, J.E. Bandow and N. Metzler-Nolte,* Organometallics, 2012, 31, 5760–5771.
DOI: http://dx.doi.org/10.1021/om201146c
2011
- Preparation and Biological Evaluation of Di-Hetero-Organometallic-Containing PNA Bioconjugate
G. Gasser,* S. Neumann, I. Ott, M. Seitz, R. Heumann and N. Metzler-Nolte,* Eur. J. Inorg. Chem., 2011, 5471-5478.
DOI: http://dx.doi.org/10.10002/ejic.201100734 - Synthesis of Optically Active Ferrocene-Containing Platensimycin Derivatives with a C6-C7 Substitution Pattern
M. Patra, G. Gasser, M. Wenzel, K. Merz, J.E. Bandow N. Metzler-Nolte,* Eur. J. Inorg. Chem., 2011, 3295-3302.
DOI: http://dx.doi.org/10.1002/ejic.201100497 - Towards the Preparation of novel Re/99mTc Tricarbonyl-Containing Peptide Nucleic Acid Bioconjugates
G. Gasser,* A.M. Sosniak, A. Leonidova, H. Braband and N. Metzler-Nolte,* Aust. J. Chem., 2011, 64, 1-8 (invited contribution).
DOI: http://dx.doi.org/10.1071/CH11010
2010
- Synthesis and Biological Evaluation of Ferrocene-containing Bioorganometallics Inspired by the Antibiotic Platensimycin Lead Structure
M. Patra, G. Gasser, M. Wenzel, K. Merz, J.E. Bandow and N. Metzler-Nolte,* Organometallics, 2010, 29, 4312-4319.
DOI: http://dx.doi.org/10.1021/om100614c - Preparation, 99mTc-Labeling and Biodistribution Studies of a PNA Oligomer Containing a New Ligand Derivative of 2,2’-Dipicolylamine
G. Gasser,* K. Jäger, M. Zenker, R. Bergmann, J. Steinbach, H. Stephan* and N. Metzler-Nolte,* J. Inorg. Biochem., 2010, 104, 1133-1140.
DOI: http://dx.doi.org/10.1016/j.jinorgbio.2010.06.011 - Sequential Insertion of three Different Organometallics into a Versatile Building Block Containing a PNA Backbone
M. Patra, G. Gasser,* D. Bobukhov, K. Merz, A.V. Shtemenko and N. Metzler-Nolte,* Dalton Trans., 2010, 39, 5617-5619.
DOI: http://dx.doi.org/10.1039/c003589J - Synthesis and Complexation Properties of Novel Triazoyl-Based Ferrocenyl Ligands
G. Gasser,* J.D. Carr, S.J. Coles, S.J. Green, M.B. Hursthouse, S.M. Cafferkey, H. Stoeckli-Evans, and J.H.R. Tucker,* J. Organomet. Chem., 2010, 695, 249-255.
DOI: http://dx.doi.org/10.1016/j.jorganchem.2009.10.004
2009
- Thermal Melting Studies of Alkyne and Ferrocene-containing PNA Bioconjugates
A. Sosniak, G. Gasser and N. Metzler-Nolte,* Org. Biomol. Chem., 2009, 7, 4992 – 5000.
DOI: http://dx.doi.org/10.1039/b913964h - Synthesis and Biological Evaluation of Chromium Bioorganometallics Based on the Antibiotic Platensimycin Lead Structure
M. Patra, G. Gasser, K. Merz, I. Ott, J.E. Bandow and N. Metzler-Nolte,* ChemMedChem, 2009, 4, 1930-1938.
DOI: http://dx.doi.org/10.1002/cmdc.200900347 - “Four-Potential” Ferrocene Labelling of PNA Oligomers via Click Chemistry
N. Hüsken, G. Gasser, S.D. Köster and N. Metzler-Nolbe,* Bioconjugate Chem., 2009, 20, 1578–1586.
DOI: http://dx.doi.org/10.1021/bc9001272 - Synthesis and Characterisation of Hetero-Bimetallic Organometallic Phenylalanine and PNA Monomer Derivatives
G. Gasser, O. Brosch, A. Ewers, T. Weyhermüller and N. Metzler-Nolte,* Dalton Trans., 2009, 4310-4317. Selected as HOT ARTICLE
DOI: http://dx.doi.org/10.1039/b819169g - Synthesis, Spectroscopic Properties and Electrochemical Oxidation of RuII Complexes Attached to a Peptide Nucleic Acid Monomer Backbone
N. Nickita, G. Gasser, A.M. Bond and L. Spiccia,* Eur. J. Inorg. Chem., 2009, 14, 2179-2186.
DOI: http://dx.doi.org/10.1002/ejic.200801259 - Synthesis and Characterisation of Dicobalthexacarbonyl-Alkyne Amino Acid, Peptide and PNA Monomer Derivatives
G. Gasser, M.A. Neukamm, A. Ewers, O. Brosch, T. Weyhermüller and N. Metzler-Nolte,* Inorg. Chem., 2009, 48, 3157-3166.
DOI: http://dx.doi.org/10.1021/ic900013r - Binding of HIV-1TAR mRNA to a Peptide Nucleic Acid Oligomer and its Conjugates with Metal-Ion-Binding Multidentate Ligands
M.J. Belousoff, G. Gasser, B. Graham, Y. Tor and L. Spiccia,* J. Biol. Inorg. Chem., 2009, 14, 287-300.
DOI: http://dx.doi.org/10.1007/s00775-008-0448-6 - Ruthenium(II) Complexes Incorporating 2-Pyridyl-2-Pyrimidine-4-Carboxylic acid
N. Nickita, G. Gasser, P. Pearson, L.Y. Goh, A.M. Bond, G.B. Deacon and L. Spiccia,* Inorg. Chem., 2009, 48, 68-81.
DOI: http://dx.doi.org/10.1021/ic800972x
2008
- Spectroscopic and Electrochemical Studies of Ferrocenyl Triazole Amino Acid and Peptide Bioconjugates Synthesized by Click Chemistry
S. D. Köster, J. Diettrich, G. Gasser N. Hüsken, I.C. Henao Castañeda, J.L. Jios, C.O. Della Védova, and N. Metzler-Nolte,* Organometallics, 2008, 27,6326–6332.
DOI: http://dx.doi.org/10.1021/om800639m - Synthesis of Organometallic PNA Oligomers by Click Chemistry
G. Gasser, N. Hüsken, S.D. Köster and N. Metzler-Nolte,* Chem. Commun., 2008, 3675-3677.
DOI: http://dx.doi.org/10.1039/b805369c - Synthesis of a Ferrocenyl Uracil PNA Monomer for Insertion into PNA Sequences
G. Gasser and L. Spiccia,* J. Organomet. Chem., 2008, 693, 2478-2482.
DOI: http://dx.doi.org/10.1016/j.jorganchem.2008.05.009 - Synthesis, Copper(II) Complexation, 64Cu-Labeling and Bioconjugation of a New Bis(2-pyridylmethyl) Derivative of 1,4,7-triazacyclonane
G. Gasser, L. Tjioe, B. Graham,* M.J. Belousoff, S. Juran, J.-U. Künstler, M. Walther, R. Bergmann, H. Stephan* and L. Spiccia,* Bioconjugate Chem., 2008, 19, 719-730.
DOI: http://dx.doi.org/10.1021/bc700396e
2007
- Synthesis, Structure, Spectroscopic Properties and Electrochemical Oxidation of Ruthenium(II) Complexes Incorporating Monocarboxylate Bipyridine Ligands
N. Nickita, M.J. Belousoff, A.I. Bhatt, A.M. Bond, G.B. Deacon, G. Gasser and L. Spiccia,* Inorg. Chem., 2007, 46, 8638-8651.
DOI: http://dx.doi.org/10.1021/ic700796m - Products of Hydrolysis of (Ferrocenylmethyl)trimethylammonium Iodide: Synthesis of Hydroxymethylferrocene and Bis(ferrocenylmethyl) Ether
G. Gasser, A.J. Fischmann, C.M. Forsyth and L. Spiccia,* J. Organomet. Chem., 2007, 692, 3835-3840.
DOI: http://dx.doi.org/10.1016/j.jorganchem.2007.05.020 - Binding of Nitrate to a CuII-Cyclen Complex Bearing a Ferrocenyl Pendant: Synthesis, Solid State X-ray Structure and Solution Phase Electrochemical and Spectrophotometric Studies
G. Gasser, M.J. Belousoff, A.M. Bond and L. Spiccia,* Inorg. Chem., 2007, 46, 3876-3888.
DOI: http://dx.doi.org/10.1021/ic061622+ - Recognition of Thymine and Related Nucleosides by a ZnII-Cyclen Complex Bearing a Ferrocenyl Pendant
G. Gasser, M.J. Belousoff, A.M. Bond, Z. Kosowski and L. Spiccia,* Inorg. Chem. 2007, 46, 1665-1674.
DOI: http://dx.doi.org/10.1021/ic061902p
2006
- Facile Synthesis and Detailed Characterization of a New Ferrocenyl Uracil Peptide Nucleic Acid Monomer
G. Gasser, M.J. Belousoff, A.M. Bond and L. Spiccia,* J. Org. Chem., 2006, 71, 7565-7573.
DOI: http://dx.doi.org/10.1021/jo060868t
2005
- Selective Electrochemical Sensing of Acidic Organic Molecules via a Novel Guest-to-Host Proton Transfer Reaction
H. Miyaji, G. Gasser, S.J. Green, Y. Molard, S.M. Strawbridge and J.H.R. Tucker,* Chem. Commun., 2005, 5355-5357.
DOI: http://dx.doi.org/10.1039/b510513g
2004
- A Heterodifunctionalised Ferrocene Derivative that Self-assembles in Solution through Complementary Hydrogen-Bonding Interactions
H. Miyaji, M. Dudic, G. Gasser, S.J. Green, G. Labat, N. Moran, I. Prokes, H. Stoeckli-Evans, S.M. Strawbridge and J.H.R. Tucker,* Dalton Trans., 2004, 18, 2831-2832.
DOI: http://dx.doi.org/10.1039/B409533B - Binding and Electrochemical Recognition of Barbiturate and Urea Derivatives by a Regioisomeric Series of Hydrogen-Bonding Ferrocene Receptors
J. Westwood, S.J. Coles, S.R. Collinson, G. Gasser, S.J. Green, M.B. Hursthouse, M.E. Light and J.H.R. Tucker,* Organometallics, 2004, 23, 946-951.
DOI: http://dx.doi.org/10.1021/om034217o