Reviews & Perspectives

All Pages

  1. Stimuli-Responsive Metal Complexes for Biomedical Applications
    I. Amarsy, S. Papot* and G. Gasser,* Angew. Chem. Int. Ed., 2022, accepted.
    DOI: https://doi.org/10.1002/anie.202205900
  2. Bifunctional Chelators for Radiorhenium: Past, Present and Future Outlook
    D.R. Melis, A.R. Burgoyne,* M. Ooms* and G. Gasser,* RSC Med. Chem., 2022, 13, 217–245.
    DOI: http://dx.doi.org/10.1039/D1MD00364J OPEN ACCESS
  3. Phototherapeutic Strategies with First-Row Transition Metal Complexes: a Critical Review
    L. Gourdon, K. Cariou and G. Gasser,* Chem. Soc. Rev., 2022, 51, 1167-1195.
    DOI: http://dx.doi.org/10.1039/d1cs00609f OPEN ACCESS
  4. Recent Approaches towards the Development of Ru(II) Polypyridyl Complexes for Anticancer Photodynamic Therapy
    Gandioso, K. Purkait and G. Gasser,* Chimia, 2021, 75, 845-855 (invited article for the special issue on photochemistry).
    DOI: http://dx.doi.org/10.2533/chimia.2021.845 OPEN ACCESS
  5. Antitumor Immune Response triggered by Metal-based Photosensitizers for Photodynamic Therapy: Where are we?
    A.C. Jung,* F. Moinard-Butot, C. Thibaudeau, G. Gasser and C. Gaiddon,* Pharmaceutics, 2021, 13, 1788.
    DOI: http://dx.doi.org/10.3390/pharmaceutics13111788 OPEN ACCESS
  6. The Race for Hydroxamate-Based Zirconium-89 Chelators
    I.V.J. Feiner, M. Brandt, J. Cowell, T. Demuth, D. Vugts, G. Gasser and T. Mindt. Cancers, 2021, 13, 4466.
    DOI: https://doi.org/10.3390/cancers13174466 OPEN ACCESS
  7. Recent Developments of Metal-based Compounds against Fungal Pathogens
    Y. Lin, H. Betts, S. Keller, K. Cariou,* and G. Gasser,* Chem. Soc. Rev., 2021, 50, 10346-10402.
    DOI: https://doi.org/10.1039/D0CS00945H
  8. Enzymatic Construction of Metal-Mediated Nucleic Acid Base Pairs
    M. Flamme, C. Figazzolo, G. Gasser, and M. Hollenstein,* Metallomics, 2021, 18, mfab016 .
    DOI: https://doi.org/10.1093/mtomcs/mfab016
  9. Ruthenium Polypyridyl Complex-Containing Bioconjugates
    M. Martinez-Alonso* and and G. Gasser,* Coord. Chem. Rev., 2021, 434, 213736 (invited article for the special issue for the 44th International Conference on Coordination Chemistry).
    DOI: https://doi.org/10.1016/j.ccr.2020.213736
  10. Unveiling the Potential of Transition Metal Complexes for Medicine: Translational in situ Activation of Metal-based Drugs from Bench to in vivo Applications
    M.J.S.A. Silva, P.M.P. Gois,* and G. Gasser,* ChemBioChem., 2021, 22, 1740-1742.
    DOI: http://dx.doi.org/10.1002/cbic.202100015
  11. Incorporation of Ru(II) Polypyridyl Complexes into Nanomaterials for Cancer Therapy and Diagnostics
    N. Soliman, G. Gasser,* and C.M. Thomas,* Adv. Mat., 2020, 32, 2003294.
    DOI: https://doi.org/10.1002/adma.202003294
  12. Critical Discussion of the Applications of Metal Complexes for 2-Photon Photodynamic Therapy
    J. Karges*, H. Chao,* and G. Gasser,* J. Biol. Inorg. Chem., 2020, 25, 1035-1050.
    DOI: http://dx.doi.org/10.1007/s00775-020-01829-5
  13. First Workshop on Metals in Medicine (2019): Translational Research in Medicinal Bioinorganic Chemistry
    A. Notaro and G. Gasser,* ChemBioChem, 2020, 21, 2706-2707 (invited editorial for the issue on the 1st workshop on Metals in Medicine in Paris).
    DOI: http://dx.doi.org/10.1002/cbic.202000329
  14. Organometallic Compounds in Drug Discovery: Past, Present and Future
    Y.C. Ong and G. Gasser,* Drug. Discov. Today Technol., 2019, accepted. (invited article for the special issue “Tropical Diseases, New Targets, New Therapies”).
    DOI: http://dx.doi.org/10.1016/j.ddtec.2019.06.001
  15. A Tutorial for the Assessment of the Stability of Organometallic Complexes in Biological Media
    S. Keller, Y.C. Ong, L. Yan, K. Cariou* and G. Gasser,* J. Organomet. Chem., 2020, 906, 121059(invited contribution for the special issue on the 8th International Symposium on Bioorganometallic Chemistry).
    DOI: http://dx.doi.org/10.1016/j.jorganchem.2019.121059
  16. Metal-based Photosensitizers for Photodynamic Therapy: a Part of Future of Multimodal Oncology?
    S. McFarland,* A. Mandel, R. Dumoulin-White and G. Gasser,* Curr. Op. Chem. Biol, 2020, 46, 5771-5804. (invited article for the special issue “Next Generation Therapeutics”).
    DOI: http://dx.doi.org/10.1016/j.chempr.2019.10.013
  17. Polymetallic Complexes for Applications as Photosensitisers in Anticancer Photodynamic Therapy
    P.S. Felder, S. Keller and G. Gasser,* Adv. Ther., 2020, 3, 1900139(invited article).
    DOI: http://dx.doi.org/10.1002/adtp.201900139
  18. Classification of Metal-Based Drugs According to Their Mechanisms of Actions
    E. Boros,* P.J. Dyson* and G. Gasser,* Chem, 2020, 6, 41-60.
    DOI: http://dx.doi.org/10.1016/j.chempr.2019.10.013
  19. Polymer Encapsulation of Ruthenium Complexes for Biological and Medicinal Applications
    E. Villemin, Y.C. Ong, C. M. Thomas* and G. Gasser,* Nature. Rev. Chem., 2019, 3, 261-282.
    DOI: http://dx.doi.org/10.1038/s41570-019-0088-0
  20. Metal Complexes against Tropical Neglected Diseases
    Y.C. Ong, S. Roy, P. Andrews,* and G. Gasser,* Chem. Rev., 2019, 119, 730-796. (invited article to the special issue on Metals in Medicine).
    DOI: http://dx.doi.org/10.1021/acs.chemrev.8b00338
  21. Mechanisms of Action of Ru(II) Polypyridyl Complexes in Living Cells upon Light Irradiation
    M. Jakubaszek, B. Goud, S. Ferrari, and G. Gasser,* Chem. Commun., 201854, 13040-13059. (Invited Feature Article).
    DOI: http://dx.doi.org/10.1039/C8CC05928D
  22. Applications of Ruthenium Complexes covalently linked to Nucleic Acid Derivatives
    M. Flamme, E. Clarke, G. Gasser,* and M. Hollenstein,* Molecules, 2018, 23, 1515 (article for the special issue on Oligonucleotides Application to Nano- and Biotechnology (DNA Origami, DNA Machine)).
    DOI: http://www.mdpi.com/1420-3049/23/7/1515/pdf OPEN ACCESS
  23. An Overview on PET Radiochemistry: Part 2 – Radiometals
    M. Brandt, J. Cardinale, M.L. Aulsebrook, G. Gasser, and T.L. Mindt,* J. Nucl. Med., 2018, 59, 1500-1506 (invited contribution).
    DOI: http://dx.doi.org/10.2967/jnumed.117.190801
  24. Harnessing the Coordination Chemistry of 1,4,7-Triazacyclononane for Biomimicry and Radiopharmaceutical Applications
    T.Joshi,* M. Kubeil, A. Nsubuga, G. Singh, G. Gasser,* and H. Stephan,* ChemPlusChem, 2018, 83, 554-564 (invited article for the special issue dedicated to the late Prof. Leone Spiccia).
    DOI: http://dx.doi.org/10.1002/cplu.201800103
  25. Critical Overview of the Use of Ru(II) Polypyridyl Complexes as Photosensitizers in One-Photon and Two-Photon Photodynamic Therapy
    F. Heinemann, J. Karges and G. Gasser,* Acc. Chem. Res., 2017, 50, 2727-2736 (invited contribution).
    DOI: http://dx.doi.org/10.1021/acs.accounts.7b00180
  26. Monomeric and Dimeric Coordinatively Saturated and Substitutionally Inert Ru(II) Polypyridyl Complexes as Anticancer Drug Candidates
    A. Notaro and G. Gasser,* Chem. Soc. Rev., 2017, 46, 7317-7337.
    DOI: http://dx.doi.org/10.1039/C7CS00356K
  27. The Medicinal Chemistry of Ferrocene and its Derivatives
    Patra* and G. Gasser,* Nat. Rev. Chem., 2017, 1, 0066 (invited contribution).
    DOI: http://dx.doi.org/10.1038/s41570-017-0066
  28. New Insights into the Pretargeting Approach to Image and Treat Tumours
    M. Patra, K. Zarschler,* H.-J. Pietzsch, H. Stephan, G. Gasser,* Chem. Soc. Rev., 2016, 45, 6415-6431.
    DOI: http://dx.doi.org/10.1039/c5cs00784d OPEN ACCESS
  29. Metal Complexes and Medicine: A Succesful Combination
    G. Gasser,* Chimia, 2015, 7, 442-446 (invited article for the special issue dedicated to the SCS Laureates and Awards 2015).
    DOI: http://dx.doi.org/10.2533/chimia.2015.442
  30. Toward Organometallic Antischistosomal Drug Candidates
    J. Hess and J. Keiser, G. Gasser,* Future Med. Chem., 2015, 8, 821-830 (invited article for a special issue on schistosomiasis).
    DOI: http://dx.doi.org/10.4155/fmc.15.22 OPEN ACCESS
  31. Lightening up Ru Complexes to fight Cancer?
    C. Mari and G. Gasser,* Chimia, 2015, 69, 176-181 (invited article to the special issue “Laureates of the SCS Fall Meeting 2014”.
    DOI: http://dx.doi.org/10.2533/chimia.2015.176
  32. Combination of Ru(II) Complexes and Light: New Frontiers in Cancer Therapy
    C. Mari, V. Pierroz, S. Ferrari and G. Gasser,* Chem. Sci, 2015, 69, 2660-2686.
    DOI: http://dx.doi.org/10.1039/C4SC03759F OPEN ACCESS
  33. Towards Tris(diimine)-Ru(II) and Bis(quinoline) Re(I)(CO)3 Complexes as Photoactivated Anticancer Drug Candidates
    T. Joshi* and G. Gasser,* Synlett, 2015, 26, 275-284 (invited article).
    DOI: http://dx.doi.org/10.1055/s-0034-1379426
  34. Underestimated Potential of Rhenium Complexes as Anticancer Agents
    A. Leonidova and G. Gasser,* ACS Chem. Biol., 2014, 9, 2180-2193 (invited article).
    DOI: http://dx.doi.org/10.1021/cb500528c
  35. Peptide Nucleic Acid – an Opportunity for Bio-Nanotechnology
    P. Anstätt and G. Gasser,* Chimia, 2014, 68, 264-268 (invited article for the special issue “Laureates of the SCS Fall Meeting 2013”).
    DOI: http://dx.doi.org/10.2533/chimia.2014.264
  36. Organometallic Compounds, an Opportunity for Chemical Biology?
    M. Patra and G. Gasser,* ChemBioChem, 2012, 13, 1232 – 1252 (invited article).
    DOI: http://dx.doi.org/10.1002/cbic.201200159
    One of the most cited articles in ChemBioChem of the years 2011 and 2012.
  37. The Potential of Organometallic Compounds in Medicinal Chemistry
    G. Gasser* and N. Metzler-Nolte,* Curr. Op. Chem. Biol., 2012, 16, 84-91.
    DOI: http://dx.doi.org/10.1016/j.cbpa.2012.01.013
  38. Small Organometallic Compounds as Antibacterial Agents
    M. Patra, G. Gasser* and N. Metzler-Nolte,* Dalton Trans., 2012, 41, 6350-6358.
    DOI: http://dx.doi.org/10.1039/c2dt12460b
  39. Metal-Containing Peptide Nucleic Acid Conjugates
    G. Gasser,* A.M. Sosniak and N. Metzler-Nolte,* Dalton Trans., 2011, 40, 7061-7076 (selected for the cover picture).
    DOI: http://dx.doi.org/10.1039/c0dt01706j
  40. Organometallic Anticancer Compounds
    G. Gasser,* I. Ott* and N. Metzler-Nolte,* J. Med. Chem., 2011, 54, 3-25.
    DOI: http://dx.doi.org/10.1021/jm100020w OPEN ACCESS
    Highly cited article in J. Med. Chem. of the year 2011