Dr. Luke McKenzie
Institute of Chemistry for Life and Health Sciences
Laboratory for Inorganic Chemical Biology
+33 1 44 27 56 03
Luke was born in Botswana but left for the UK when still a toddler. Having completed undergraduate chemistry at the University of Sheffield Luke then undertook a PhD project working for Dr Helen Bryant and Prof Julia Weinstein exploring various Ir(III), Pt(II) and Os(II) complexes as potential photosensitizers for photodynamic therapy. He is currently in Paris on an ARC foundation postdoctoral fellowship working between Dr Gasser’s group at Chimie ParisTech and Dr Marcel Hollenstein’s group at Institut Pasteur to develop targeted Ru(II) photosensitizers.
Luke loves food, drink and travel.
- Saeed HK, Jarman PJ, Archer S, Sreedharan S, Saeed IK, Mckenzie LK, Weinstein JA, Buurma NJ, Smythe CGW, Thomas JA. Homo- and heteroleptic phototoxic dinuclear metallo-intercalators based on RuII(dppn) intercalating moieties: synthesis, optical and biological studies. Chem. Int. Ed. 2017 (Accepted manuscript online)
- McKenzie LK, Sazanovich IV, Baggaley E, Bonneau M, Guerchais V, Williams JA, Weinstein JA, Bryant HE. Metal Complexes for Two-Photon Photodynamic Therapy: A Cyclometallated Iridium Complex Induces Two-Photon Photosensitization of Cancer Cells under Near-IR Light. Chem. Eur. J. 2017 Jan 5;23(2):234-238.
- Omar SA, Scattergood PA, McKenzie LK, Bryant HE, Weinstein JA, Elliott PI. Towards Water Soluble Mitochondria-Targeting Theranostic Osmium(II) Triazole-Based Complexes. Molecules. 2016 Oct 18;21(10).
- Jana A, Crowston BJ, Shewring JR, McKenzie LK, Bryant HE, Botchway SW, Ward, AD, Amoroso AJ, Baggaley E, Ward MD. Heteronuclear Ir(III)-Ln(III) Luminescent Complexes: Small-Molecule Probes for Dual Modal Imaging and Oxygen Sensing. Inorg Chem. 2016 Jun 6;55(11):5623-33.
- Walker MG, Jarman PJ, Gill MR, Tian X, Ahmad H, Reddy PA, McKenzie L, Weinstein JA, Meijer AJ, Battaglia G, Smythe CG, Thomas JA. A Self-Assembled Metallomacrocycle Singlet Oxygen Sensitizer for Photodynamic Therapy. Eur. J. 2016 Apr 18;22(17):5996-6000.
- Jana A, McKenzie L, Wragg AB, Ishida M, Hill JP, Weinstein JA, Baggaley E, Ward MD. Porphyrin/Platinum(II) C^N^N Acetylide Complexes: Synthesis, Photophysical Properties, and Singlet Oxygen Generation. Chem. Eur. J. 2016 Mar14;22(12):4164-74.
- Doherty RE, Sazanovich IV, McKenzie LK, Stasheuski AS, Coyle R, Baggaley E, Bottomley S, Weinstein JA, Bryant HE. Photodynamic killing of cancer cells by a Platinum(II) complex with cyclometallating ligand. Sci Rep. 2016 Mar 4;6:22668.
- Wragg A, Gill MR, McKenzie L, Glover C, Mowll R, Weinstein JA, Su X, Smythe C, Thomas JA. Serum Albumin Binding Inhibits Nuclear Uptake of Luminescent Metal-Complex-Based DNA Imaging Probes. Eur. J. 2015 Aug 10;21(33):11865-71.