New article accepted in J. Inorg. Biochem.!

Our paper “Preparation, 99mTc-Labeling and Biodistribution Studies of a PNA Oligomer Containing a New Ligand Derivative of 2,2´-Dipicolylamine” was accepted in J. Inorg. Biochem. This paper presents the facile preparation of a novel bifunctional chelating for 99mTc (DPA-N3). Dpa-N3 was successfully coupled, on the solid phase, to a Peptide Nucleic Acid (PNA) oligomer employing the Click Chemistry methodology to give the expected oligomer Dpa-PNA. Subsequent labeling of Dpa-PNA with [99mTc(H2O)3(CO)3]+ afforded [99mTc(CO)3(Dpa-PNA)] in radiochemical yields > 90%. Biodistribution studies of [99mTc(CO)3(Dpa-PNA)] in Wistar rats showed a fast blood clearance and only a modest accumulation in the kidneys. Similar results were found when a mouse model (NMRI nu/nu) was used.

New article accepted in J. Inorg. Biochem.!

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